Gene
scube1
- ID
- ZDB-GENE-050302-78
- Name
- signal peptide, CUB domain, EGF-like 1
- Symbol
- scube1 Nomenclature History
- Previous Names
-
- im:7427863
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including cell surface receptor signaling pathway; primitive hemopoiesis; and sprouting angiogenesis. Located in plasma membrane. Is expressed in several structures, including axial chorda mesoderm; blastomere; central nervous system; optic cup; and solid lens vesicle. Orthologous to human SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-scube1 | N/A | (2) |
| MO2-scube1 | N/A | Johnson et al., 2012 |
| MO3-scube1 | N/A | (2) |
| TALEN1-scube1 | Tsao et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Complement Clr-like EGF domain | CUB domain | EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | NOTCH1 EGF-like calcium-binding domain | Signal peptide, CUB and EGF-like domain-containing protein | Spermadhesin, CUB domain superfamily | Tyrosine-protein kinase ephrin type A/B receptor-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PAA2 | InterPro | 1024 | ||||||||||||
| UniProtKB:A0A0R4IBT9 | InterPro | 994 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
scube1-201
(1)
|
Ensembl | 4,038 nt | ||
| mRNA |
scube1-203
(1)
|
Ensembl | 3,689 nt | ||
| ncRNA |
scube1-002
(1)
|
Ensembl | 1,068 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-375O18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-48P11 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7427863 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328599 (1) | 3779 nt | ||
| Genomic | GenBank:CT573393 (2) | 189027 nt | ||
| Polypeptide | UniProtKB:A0A8M1PAA2 (1) | 1024 aa |
- Comparative Orthology
- Alliance
- Tsao, K.C., Lin, Y.C., Chen, Y.T., Lai, S.L., Yang, R.B. (2021) Zebrafish scube1 and scube2 cooperate in promoting Vegfa signaling during embryonic vascularization. Cardiovascular research. 118(4):1074-1087
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Liao, W.J., Tsao, K.C., Yang, R.B. (2016) Electrostatics and N-glycan-mediated membrane tethering of SCUBE1 is critical for promoting bone morphogenetic protein signalling. The Biochemical journal. 473(5):661-72
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Marquart, G.D., Tabor, K.M., Brown, M., Strykowski, J.L., Varshney, G.K., LaFave, M.C., Mueller, T., Burgess, S.M., Higashijima, S., Burgess, H.A. (2015) A 3D Searchable Database of Transgenic Zebrafish Gal4 and Cre Lines for Functional Neuroanatomy Studies. Frontiers in neural circuits. 9:78
- Tsao, K.C., Tu, C.F., Lee, S.J., and Yang, R.B. (2013) Zebrafish scube1 [signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF domain-containing protein 1] Is Involved in Primitive Hematopoiesis. The Journal of biological chemistry. 288(7):5017-5026
- Johnson, J.L., Hall, T.E., Dyson, J.M., Sonntag, C., Ayers, K., Berger, S., Gautier, P., Mitchell, C., Hollway, G.E., and Currie, P.D. (2012) Scube activity is necessary for Hedgehog signal transduction in vivo. Developmental Biology. 368(2):193-202
- Hollway, G.E., Maule, J., Gautier, P., Evans, T.M., Keenan, D.G., Lohs, C., Fischer, D., Wicking, C., and Currie, P.D. (2006) Scube2 mediates Hedgehog signalling in the zebrafish embryo. Developmental Biology. 294(1):104-118
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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