Gene

baxb

ID

ZDB-GENE-050227-21

Name

BCL2 associated X, apoptosis regulator b

Symbol

baxb Nomenclature History

Previous Names

zBax2 (1)
zgc:112983 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable channel activity. Acts upstream of or within positive regulation of apoptotic process. Predicted to be active in mitochondrial outer membrane. Is expressed in eye; gut; heart; kidney; and ovary. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Orthologous to human BAX (BCL2 associated X, apoptosis regulator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 12 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With baxb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute lymphoblastic leukemia	Alliance	T-cell acute lymphoblastic leukemia, somatic	613065
colorectal cancer	Alliance	Colorectal cancer, somatic	114500

Associated With baxb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR046371	Bcl-2, Bcl-2 homology region 1-3
Family	IPR002475	Bcl2-like
Family	IPR026298	Bcl-2 family
Homologous_superfamily	IPR036834	Bcl-2-like superfamily