Gene
gadd45bb
- ID
- ZDB-GENE-050223-1
- Name
- growth arrest and DNA-damage-inducible, beta b
- Symbol
- gadd45bb Nomenclature History
- Previous Names
-
- gadd45b1 (1)
- gadd45bl
- zgc:112453
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Acts upstream of or within somitogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including margin; mesoderm; musculature system; solid lens vesicle; and yolk syncytial layer. Orthologous to human GADD45B (growth arrest and DNA damage inducible beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112453 (12 images)
- eu542 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la023646Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa31288 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 2 of 2
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-gadd45bb | N/A | Kawahara et al., 2005 |
MO2-gadd45bb | N/A | Chen et al., 2016 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Growth arrest and DNA damage-inducible protein GADD45 | Ribosomal protein eL30-like superfamily | Ribosomal protein eL8/eL30/eS12/Gadd45 |
---|---|---|---|---|---|
UniProtKB:Q5NU21 | InterPro | 158 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
gadd45bb-201
(1)
|
Ensembl | 1,390 nt | ||
ncRNA |
gadd45bb-002
(1)
|
Ensembl | 783 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-193B15 | ZFIN Curated Data | |
Encodes | EST | eu542 | Thisse et al., 2005 | |
Encodes | cDNA | MGC:112453 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192984 | ZFIN Curated Data |
1 - 4 of 4
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001012386 (1) | 1264 nt | ||
Genomic | GenBank:BX470229 (1) | 241018 nt | ||
Polypeptide | UniProtKB:Q5NU21 (1) | 158 aa |
- Kong, S., Xiao, Y., Chen, L., Jin, Y., Qiao, R., Xu, K., Xu, L., Wang, H. (2024) Apigenin attenuates cisplatin-induced hair cell damage in the zebrafish lateral line. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 194:115099
- Sun, C.C., Yang, D., Chen, Z.L., Xiao, J.L., Xiao, Q., Li, C.L., Zhou, Z.Q., Peng, X.Y., Tang, C.F. (2022) Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction. The FEBS journal. 290(6):1519-1530
- Sun, C.C., Zhou, Z.Q., Chen, Z.L., Zhu, R.K., Yang, D., Peng, X.Y., Zheng, L., Tang, C.F. (2021) Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Biology. 10(8):
- Huang, W., Zheng, S., Wang, X., Cai, Z., Xiao, J., Liu, C., Wu, K. (2020) A transcriptomics-based analysis of toxicity mechanisms of zebrafish embryos and larvae following parental Bisphenol A exposure. Ecotoxicology and environmental safety. 205:111165
- Huang, W., Zheng, S., Xiao, J., Liu, C., Du, T., Wu, K. (2020) Parental exposure to bisphenol A affects pharyngeal cartilage development and causes global transcriptomic changes in zebrafish (Danio rerio) offspring. Chemosphere. 249:126537
- Nguyen, T.H., Le, H.D., Kim, T.N.T., The, H.P., Nguyen, T.M., Cornet, V., Lambert, J., Kestemont, P. (2020) Anti-Inflammatory and Antioxidant Properties of the Ethanol Extract of Clerodendrum Cyrtophyllum Turcz in Copper Sulfate-Induced Inflammation in Zebrafish. Antioxidants (Basel, Switzerland). 9(3):
- Nguyen, T.H., Nguyen, P.D., Quetin-Leclercq, J., Muller, M., Ly Huong, D.T., Pham, H.T., Kestemont, P. (2020) Developmental toxicity of Clerodendrum cyrtophyllum turcz ethanol extract in zebrafish embryo. Journal of ethnopharmacology. 267:113538
- Xu, H., Jiang, Y., Li, S., Xie, L., Tao, Y.X., Li, Y. (2020) Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging. Genes. 11(10):
- Zhai, X., Wang, L., Xu, C., Hou, Q., Zhang, L., Li, Z., Qin, W., Liu, Z., Chen, Z. (2019) Triptolide preserves glomerular barrier function via the inhibition of p53-mediated increase of GADD45B. Archives of biochemistry and biophysics. 671:210-217
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
1 - 10 of 30
Show