Gene
gna12a
- ID
- ZDB-GENE-050221-1
- Name
- guanine nucleotide binding protein (G protein) alpha 12a
- Symbol
- gna12a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Acts upstream of or within several processes, including gastrulation; glial cell development; and negative regulation of cell-cell adhesion mediated by cadherin. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in brush border membrane and cytoplasm. Is expressed in brain; gill; head; and olfactory epithelium. Orthologous to human GNA12 (G protein subunit alpha 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
nksagm18cGt | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR000469 | G-protein alpha subunit, group 12/13 |
Family | IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit |
Homologous_superfamily | IPR011025 | G protein alpha subunit, helical insertion |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
Protein | Additional Resources | Length | G-protein alpha subunit, group 12/13 | G protein alpha subunit, helical insertion | Guanine nucleotide binding protein (G-protein), alpha subunit | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|
UniProtKB:Q5YKG4 | InterPro | 385 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
gna12a-201
(1)
|
Ensembl | 4,379 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-250F19 | ZFIN Curated Data | |
Encodes | EST | wz10433 | ZFIN Curated Data | |
Encodes | cDNA | MGC:158144 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001013277 (1) | 4423 nt | ||
Genomic | GenBank:BX324110 (1) | 103014 nt | ||
Polypeptide | UniProtKB:Q5YKG4 (1) | 385 aa |
- Nittoli, V., Fortunato, A.E., Fasano, G., Coppola, U., Gentile, A., Maiella, S., Langellotto, F., Porreca, I., De Paolo, R., Marino, R., Fiengo, M., Donizetti, A., Aniello, F., Kondo, T., Ristoratore, F., Canzoniero, L.M.T., Duboule, D., Wilson, S.W., Sordino, P. (2019) Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Gene X. 2:100011
- Ackerman, S.D., Luo, R., Poitelon, Y., Mogha, A., Harty, B.L., D'Rozario, M., Sanchez, N.E., Lakkaraju, A.K.K., Gamble, P., Li, J., Qu, J., MacEwan, M.R., Ray, W.Z., Aguzzi, A., Feltri, M.L., Piao, X., Monk, K.R. (2018) GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. The Journal of experimental medicine. 215(3):941-961
- Chen, L., Au, D.W., Hu, C., Peterson, D.R., Zhou, B., Qian, P.Y. (2017) Identification of Molecular Targets for 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in Teleosts: New Insight into Mechanism of Toxicity. Environmental science & technology. 51(3):1840-1847
- Smith, L.C., Clark, J.C., Bisesi, J.H., Ferguson, P.L., Sabo-Attwood, T. (2016) Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 19:159-73
- Ackerman, S.D., Garcia, C., Piao, X., Gutmann, D.H., Monk, K.R. (2015) The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA. Nature communications. 6:6122
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Li, P., Lahvic, J.L., Binder, V., Pugach, E.K., Riley, E.B., Tamplin, O.J., Panigrahy, D., Bowman, T.V., Barrett, F.G., Heffner, G.C., McKinney-Freeman, S., Schlaeger, T.M., Daley, G.Q., Zeldin, D.C., Zon, L.I. (2015) Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 523:468-71
- Song, S., Eckerle, S., Onichtchouk, D., Marrs, J.A., Nitschke, R., and Driever, W. (2013) Pou5f1-dependent EGF expression controls e-cadherin endocytosis, cell adhesion, and zebrafish epiboly movements. Developmental Cell. 24(5):486-501
- Ye, D., and Lin, F. (2013) S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence. Development (Cambridge, England). 140(4):789-799
- Oka, Y., and Korsching, S.I. (2011) Shared and Unique G Alpha Proteins in the Zebrafish Versus Mammalian Senses of Taste and Smell. Chemical senses. 36(4):357-365
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