Gene
gna15.4
- ID
- ZDB-GENE-050208-781
- Name
- guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4
- Symbol
- gna15.4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in action potential; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; and phospholipase C-activating dopamine receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in barbel; eye; gill; and lip. Orthologous to human GNA15 (G protein subunit alpha 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Oka et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa37509 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | G protein alpha subunit, helical insertion | Guanine nucleotide binding protein (G-protein), alpha subunit | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|
UniProtKB:Q1LW07 | InterPro | 361 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
gna15.4-201
(1)
|
Ensembl | 1,125 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-207C7 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001044989 (1) | 1086 nt | ||
Genomic | GenBank:BX901926 (1) | 204799 nt | ||
Polypeptide | UniProtKB:Q1LW07 (1) | 361 aa |
- Kanai, S.M., Garcia, C.R., Augustus, M.R., Sharafeldeen, S.A., Brooks, E.P., Sucharov, J., Lencer, E.S., Nichols, J.T., Clouthier, D.E. (2025) The Gq/11 family of Gα subunits is necessary and sufficient for lower jaw development. Development (Cambridge, England). :
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Oka, Y., and Korsching, S.I. (2011) Shared and Unique G Alpha Proteins in the Zebrafish Versus Mammalian Senses of Taste and Smell. Chemical senses. 36(4):357-365
- Oka, Y., Saraiva, L.R., Kwan, Y.Y., and Korsching, S.I. (2009) The fifth class of Gα proteins. Proceedings of the National Academy of Sciences of the United States of America. 106(5):1484-1489
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