Gene
sirt7
- ID
- ZDB-GENE-050208-612
- Name
- sirtuin 7
- Symbol
- sirt7 Nomenclature History
- Previous Names
-
- si:ch211-258l4.6 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable histone H3K18 deacetylase activity, NAD-dependent; protein-glutaryllysine deglutarylase activity; and protein-succinyllysine desuccinylase activity. Acts upstream of or within antiviral innate immune response; hematopoietic progenitor cell differentiation; and response to hypoxia. Predicted to be located in site of double-strand break. Predicted to be active in chromatin and nucleus. Is expressed in retina. Orthologous to human SIRT7 (sirtuin 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu987 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Huang et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DHS-like NAD/FAD-binding domain superfamily | NAD-dependent sirtuin protein deacylases | Sirtuin family | Sirtuin family, catalytic core domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QUG9 | InterPro | 405 |
Interactions and Pathways
No data available
Plasmids
No data available