Gene
sirt7
- ID
- ZDB-GENE-050208-612
- Name
- sirtuin 7
- Symbol
- sirt7 Nomenclature History
- Previous Names
-
- si:ch211-258l4.6 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable histone H3K18 deacetylase activity, NAD-dependent; protein-glutaryllysine deglutarylase activity; and protein-succinyllysine desuccinylase activity. Acts upstream of or within antiviral innate immune response; hematopoietic progenitor cell differentiation; and response to hypoxia. Predicted to be located in site of double-strand break. Predicted to be active in chromatin and nucleus. Is expressed in retina. Orthologous to human SIRT7 (sirtuin 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu987 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Huang et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihblqs4 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ihblqs7 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ihblqs44 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| sa24226 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30735 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sirt7 | (5) | |
| CRISPR2-sirt7 | Brocal et al., 2016 | |
| MO1-sirt7 | N/A | Huang et al., 2013 |
| MO2-sirt7 | N/A | Huang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DHS-like NAD/FAD-binding domain superfamily | NAD-dependent sirtuin protein deacylases | Sirtuin family | Sirtuin family, catalytic core domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QUG9 | InterPro | 405 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-258L4 | ZFIN Curated Data | |
| Encodes | EST | eu987 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001336402 (1) | |||
| Genomic | GenBank:AL953867 (1) | 177575 nt | ||
| Polypeptide | UniProtKB:A0A2R8QUG9 (1) | 405 aa |
- Gupta, S., Hui, S.P. (2024) Epigenetic Cross-Talk Between Sirt1 and Dnmt1 Promotes Axonal Regeneration After Spinal Cord Injury in Zebrafish. Molecular neurobiology. :
- Tian, Y., Lautrup, S., Law, P.W.N., Dinh, N.D., Fang, E.F., Chan, W.Y. (2024) WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome. Cell & Bioscience. 14:77
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Liao, Q., Zhu, C., Sun, X., Wang, Z., Chen, X., Deng, H., Tang, J., Jia, S., Liu, W., Xiao, W., Liu, X. (2023) Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance. The Journal of biological chemistry. 299(8):105074
- Ding, Q., Zhang, Z., Li, Y., Liu, H., Hao, Q., Yang, Y., Ringø, E., Olsen, R.E., Clarke, J.L., Ran, C., Zhou, Z. (2021) Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish. iScience. 24:102515
- Liao, Q., Ouyang, G., Zhu, J., Cai, X., Yu, G., Zhou, Z., Liu, X., Wang, J., Xiao, W. (2021) Zebrafish sirt7 Negatively Regulates Antiviral Responses by Attenuating Phosphorylation of irf3 and irf7 Independent of Its Enzymatic Activity. Journal of immunology (Baltimore, Md. : 1950). 207(12):3050-3059
- Fellous, A., Earley, R.L., Silvestre, F. (2019) Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (Hdac) and lysine acetyltransferase (Kat) genes. Gene. 691:56-69
- Sheng, W., Lu, Y., Mei, F., Wang, N., Liu, Z.Z., Han, Y.Y., Wang, H.T., Zou, S., Xu, H., Zhang, X. (2018) Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina. Investigative ophthalmology & visual science. 59:4542-4551
- Brocal, I., White, R.J., Dooley, C.M., Carruthers, S.N., Clark, R., Hall, A., Busch-Nentwich, E.M., Stemple, D.L., Kettleborough, R.N. (2016) Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. BMC Genomics. 17:259
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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