Gene
rdh5
- ID
- ZDB-GENE-050208-411
- Name
- retinol dehydrogenase 5 (11-cis/9-cis)
- Symbol
- rdh5 Nomenclature History
- Previous Names
-
- hsd17b9 (1)
- im:6901729
- si:dkey-102c8.5
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within eye photoreceptor cell differentiation; retina development in camera-type eye; and vitamin A biosynthetic process. Is expressed in several structures, including gut; heart; pineal complex; skeletal muscle cell; and visual system. Human ortholog(s) of this gene implicated in fundus albipunctatus and night blindness. Orthologous to human RDH5 (retinol dehydrogenase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6901729 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-rdh5 | N/A | Nadauld et al., 2006 |
| MO2-rdh5 | N/A | Nadauld et al., 2006 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| fundus albipunctatus | Alliance | Fundus albipunctatus | 136880 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NAD(P)-binding domain superfamily | Short-chain dehydrogenase/reductase, conserved site | Short-chain dehydrogenase/reductase SDR |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2BLL9 | InterPro | 326 | |||
| UniProtKB:Q4V8Y1 | InterPro | 328 | |||
| UniProtKB:F1RCW4 | InterPro | 328 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-102C8 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6901729 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114091 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030101 (1) | 1626 nt | ||
| Genomic | GenBank:BX324213 (1) | 94824 nt | ||
| Polypeptide | UniProtKB:F1RCW4 (1) | 328 aa |
- Naef, V., Damiani, D., Licitra, R., Marchese, M., Vecchia, S.D., Baggiani, M., Brogi, L., Galatolo, D., Landi, S., Santorelli, F.M. (2025) Modeling sacsin depletion in Danio Rerio offers new insight on retinal defects in ARSACS. Neurobiology of disease. :106793106793
- Bian, L., Nguyen, V.T., Tamaoki, J., Endo, Y., Dong, G., Sato, A., Kobayashi, M. (2023) Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish. Redox Biology. 62:102673102673
- Chen, D.D., Liu, B., Wang, Y., Jiang, M., Shang, G., Xue, M., Jia, X., Lang, Y., Zhou, G., Zhang, F., Peng, X., Hu, Y. (2023) The downregulation of HSP90-controlled CRALBP expression is associated with age-related vision attenuation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22832e22832
- Li, X., Xiong, D., Ju, Z., Xiong, Y., Ding, G., Liao, G. (2020) Phenotypic and transcriptomic consequences in zebrafish early-life stages following exposure to crude oil and chemical dispersant at sublethal concentrations. The Science of the total environment. 763:143053
- Xiao, L., Guo, Y., Wang, D., Zhao, M., Hou, X., Li, S., Lin, H., Zhang, Y. (2020) Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper (Epinephelus coioides): Genome-Wide Identification and Expression Analysis During Sex Reversal. Frontiers in genetics. 11:161
- Zhang, Y., Wang, Z., Zhao, G., Liu, J.X. (2018) Silver nanoparticles affect lens rather than retina development in zebrafish embryos. Ecotoxicology and environmental safety. 163:279-288
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Khuansuwan, S., Gamse, J.T. (2014) Identification of differentially expressed genes during development of the zebrafish pineal complex using RNA sequencing. Developmental Biology. 395(1):144-53
- Belyaeva, O.V., and Kedishvili, N.Y. (2006) Comparative genomic and phylogenetic analysis of short-chain dehydrogenases/reductases with dual retinol/sterol substrate specificity. Genomics. 88(6):820-830
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