Gene
lats2
- ID
- ZDB-GENE-050119-6
- Name
- large tumor suppressor kinase 2
- Symbol
- lats2 Nomenclature History
- Previous Names
-
- si:ch211-173o4.2
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of with a negative effect on BMP signaling pathway. Acts upstream of or within convergent extension involved in gastrulation and secondary heart field specification. Predicted to be located in centrosome and spindle. Predicted to be active in nucleus and spindle pole. Is expressed in several structures, including nervous system; neural crest cell; non neural ectoderm; pectoral fin bud; and pleuroperitoneal region. Used to study peripheral nerve sheath neoplasm. Orthologous to human LATS2 (large tumor suppressor kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026802Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029554Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mw87 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ncv108 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | TALEN | |
| sa7627 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa34612 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38734 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38735 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lats2 | Brandt et al., 2019 | |
| CRISPR2-lats2 | Brandt et al., 2019 | |
| MO1-lats2 | N/A | Chen et al., 2009 |
| MO2-lats2 | N/A | (6) |
| TALEN1-lats2 | Fukui et al., 2018 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| peripheral nerve sheath neoplasm | lats2mw87/mw87 | standard conditions | Brandt et al., 2019 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinases, AGC | UBA-like superfamily | Ubiquitin-associated domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0S8I4 | InterPro | 1140 | ||||||||
| UniProtKB:B2BJC0 | InterPro | 1078 | ||||||||
| UniProtKB:B2BJC1 | InterPro | 1140 | ||||||||
| UniProtKB:A0A8M1NH44 | InterPro | 1078 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-173O4 | ZFIN Curated Data | |
| Contained in | BAC | RP71-68N21 | ZFIN Curated Data | |
| Encodes | STS | zfish44906-4818b06.p1k |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423734 (1) | 7103 nt | ||
| Genomic | GenBank:CU151884 (1) | 200118 nt | ||
| Polypeptide | UniProtKB:B0S8I4 (1) | 1140 aa |
- Li, M., Wang, R., Yan, T., Tao, X., Gao, S., Wang, Z., Chai, Y., Qiu, S., Chen, W. (2024) Dual effects of DLG5 (disks large homolog 5 gene) modulation on chemotherapy-induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway. British journal of pharmacology. 182(4):1090-1106
- Flinn, M.A., Otten, C., Brandt, Z.J., Bostrom, J.R., Kenarsary, A., Wan, T.C., Auchampach, J.A., Abdelilah-Seyfried, S., O'Meara, C.C., Link, B.A. (2020) Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. Development (Cambridge, England). 147(16):
- Lundin, V., Sugden, W.W., Theodore, L.N., Sousa, P.M., Han, A., Chou, S., Wrighton, P.J., Cox, A.G., Ingber, D.E., Goessling, W., Daley, G.Q., North, T.E. (2020) YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Developmental Cell. 52(4):446-460.e5
- Brandt, Z.J., North, P.N., Link, B.A. (2019) Somatic Mutations of lats2 Cause Peripheral Nerve Sheath Tumors in Zebrafish. Cells. 8(9)
- Flinn, M.A., Jeffery, B.E., O'Meara, C.C., Link, B.A. (2018) Yap is Required for Scar Formation but not Myocyte Proliferation During Heart Regeneration in Zebrafish. Cardiovascular research. 115(3):570-577
- Fukui, H., Miyazaki, T., Chow, R.W., Ishikawa, H., Nakajima, H., Vermot, J., Mochizuki, N. (2018) Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish. eLIFE. 7
- Yi, X., Yu, J., Ma, C., Li, L., Luo, L., Li, H., Ruan, H., Huang, H. (2018) Yap1/Taz are essential for the liver development in zebrafish. Biochemical and Biophysical Research Communications. 503(1):131-137
- Mayrhofer, M., Gourain, V., Reischl, M., Affaticati, P., Jenett, A., Joly, J.S., Benelli, M., Demichelis, F., Poliani, P.L., Sieger, D., Mione, M. (2017) A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth. Disease models & mechanisms. 10(1):15-28
- Nakajima, H., Yamamoto, K., Agarwala, S., Terai, K., Fukui, H., Fukuhara, S., Ando, K., Miyazaki, T., Yokota, Y., Schmelzer, E., Belting, H.G., Affolter, M., Lecaudey, V., Mochizuki, N. (2017) Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Developmental Cell. 40:523-536.e6
- Mateus, R., Lourenço, R., Fang, Y., Brito, G., Farinho, A., Valério, F., Jacinto, A. (2015) Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration. Development (Cambridge, England). 142(16):2752-63
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