Gene
tnni1b
- ID
- ZDB-GENE-041212-37
- Name
- troponin I type 1b (skeletal, slow)
- Symbol
- tnni1b Nomenclature History
- Previous Names
-
- TnnI-HC (1)
- zgc:103458
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity. Involved in heart valve development. Acts upstream of or within heart development. Predicted to be part of troponin complex. Is expressed in cardiovascular system; lateral plate mesoderm; and musculature system. Orthologous to human TNNI1 (troponin I1, slow skeletal type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103458 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9762 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17057 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33979 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf3081 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zf3082 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tnni1b | Cai et al., 2018 | |
| MO1-tnni1b | N/A | Musso et al., 2014 |
| MO2-tnni1b | N/A | Musso et al., 2014 |
| MO3-tnni1b | N/A | Campinho et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Troponin | Troponin domain superfamily | Troponin I |
|---|---|---|---|---|---|
| UniProtKB:Q5PR62 | InterPro | 182 | |||
| UniProtKB:A0AB32TQR2 | InterPro | 166 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnni1b-201
(1)
|
Ensembl | 2,612 nt | ||
| mRNA |
tnni1b-202
(1)
|
Ensembl | 1,015 nt | ||
| mRNA |
tnni1b-203
(1)
|
Ensembl | 766 nt | ||
| mRNA |
tnni1b-204
(1)
|
Ensembl | 2,723 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-334P16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103458 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192139 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001008613 (1) | 961 nt | ||
| Genomic | GenBank:CU861466 (1) | 80121 nt | ||
| Polypeptide | UniProtKB:Q5PR62 (1) | 182 aa |
- Bradshaw, M., Squire, J.M., Morris, E., Atkinson, G., Richardson, R., Lees, J., Caputo, M., Bigotti, G.M., Paul, D.M. (2023) Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio. Journal of muscle research and cell motility. 44(3):179-192
- Liu, J., Li, W., Jin, X., Lin, F., Han, J., Zhang, Y. (2023) Optimal tagging strategies for illuminating expression profiles of genes with different abundance in zebrafish. Communications biology. 6:13001300
- Gui, Y., Zhang, Y., Zhang, Q., Chen, X., Wang, F., Wu, F., Gui, Y., Li, Q. (2022) The functional verification and analysis of Fugu promoter of cardiac gene tnni1a in zebrafish. Cells & development. 171:203801
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Liu, L., Fei, F., Zhang, R., Wu, F., Yang, Q., Wang, F., Sun, S., Zhao, H., Li, Q., Wang, L., Wang, Y., Gui, Y., Wang, X. (2019) Combinatorial genetic replenishments in myocardial and outflow tract tissues restore heart function in tnnt2 mutant zebrafish. Biology Open. 8(12):
- Cai, C., Sang, C., Du, J., Jia, H., Tu, J., Wan, Q., Bao, B., Xie, S., Huang, Y., Li, A., Li, J., Yang, K., Wang, S., Lu, Q. (2018) Knockout of tnni1b in zebrafish causes defects in atrioventricular valve development via the inhibition of the myocardial wnt signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(1):696-710
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Chen, W.C., Wang, Z., Missinato, M.A., Park, D.W., Long, D.W., Liu, H.J., Zeng, X., Yates, N.A., Kim, K., Wang, Y. (2016) Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Science advances. 2:e1600844
- Genge, C.E., Stevens, C.M., Davidson, W.S., Singh, G., Tieleman, D.P., Tibbits, G.F. (2016) Functional divergence in teleost cardiac troponin paralogs guides variation in the interaction of TnI switch region with TnC. Genome biology and evolution. 8(4):994-1011
- Gomes, R.S., Skroblin, P., Munster, A.B., Tomlins, H., Langley, S.R., Zampetaki, A., Yin, X., Wardle, F., Mayr, M. (2016) "Young at heart": Regenerative potential linked to immature cardiac phenotypes. Journal of Molecular and Cellular Cardiology. 92:105-8
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