Gene
ndrg2
- ID
- ZDB-GENE-041212-15
- Name
- NDRG family member 2
- Symbol
- ndrg2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to be involved in signal transduction. Predicted to act upstream of or within Wnt signaling pathway; cell differentiation; and nervous system development. Predicted to be active in cytoplasm. Is expressed in several structures, including intermediate cell mass of mesoderm; nervous system; optic cup; pectoral fin bud; and yolk. Orthologous to human NDRG2 (NDRG family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909381 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Wang et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-ndrg2 | Wang et al., 2023 | |
MO1-ndrg2 | N/A | Wang et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | NDRG |
---|---|---|---|---|
UniProtKB:Q5PR98 | InterPro | 368 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-353H16 | ZFIN Curated Data | |
Contained in | BAC | DKEY-88N24 | ZFIN Curated Data | |
Encodes | EST | IMAGE:6909381 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:101847 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001008593 (1) | 1793 nt | ||
Genomic | GenBank:BX284672 (2) | 149982 nt | ||
Polypeptide | UniProtKB:Q5PR98 (1) | 368 aa |
- Wang, C., Wang, X., Zheng, H., Yao, J., Xiang, Y., Liu, D. (2023) The ndrg2 Gene Regulates Hair Cell Morphogenesis and Auditory Function during Zebrafish Development. International Journal of Molecular Sciences. 24(12):
- Le, N., Hufford, T.M., Park, J.S., Brewster, R.M. (2021) Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21961
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Aceto, J., Nourizadeh-Lillabadi, R., Bradamante, S., Maier, J.A., Alestrom, P., van Loon, J.J., Muller, M. (2016) Effects of microgravity simulation on zebrafish transcriptomes and bone physiology-exposure starting at 5 days post fertilization. NPJ microgravity. 2:16010
- Li, R.A., Traver, D., Matthes, T., Bertrand, J.Y. (2016) Ndrg1b and fam49ab modulate the PTEN pathway to control T cell lymphopoiesis in the zebrafish. Blood. 128(26):3052-3060
- Aceto, J., Nourizadeh-Lillabadi, R., Marée, R., Dardenne, N., Jeanray, N., Wehenkel, L., Aleström, P., van Loon, J.J., Muller, M. (2015) Zebrafish Bone and General Physiology Are Differently Affected by Hormones or Changes in Gravity. PLoS One. 10:e0126928
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nolte, H., Hölper, S., Housley, M.P., Islam, S., Piller, T., Konzer, A., Stainier, D.Y., Braun, T., Krüger, M. (2015) Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Proteomics. 15(4):739-51
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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