Gene
stab2
- ID
- ZDB-GENE-041210-336
- Name
- stabilin 2
- Symbol
- stab2 Nomenclature History
- Previous Names
-
- si:dkey-207j16.6
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables scavenger receptor activity. Acts upstream of or within several processes, including cholesterol homeostasis; low-density lipoprotein particle clearance; and oxidised low-density lipoprotein particle clearance. Predicted to be located in membrane. Is expressed in several structures, including angioblastic mesenchymal cell; caudal hematopoietic tissue; lateral plate mesoderm; vascular cord; and vasculature. Orthologous to human STAB2 (stabilin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu7897 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| ibl2 | Allele with one delins | Unknown | Frameshift, Premature Stop | CRISPR | |
| la024772Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa57 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa1575 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa8752 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11212 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11372 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11760 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15213 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-stab2 | (5) | |
| MO1-stab2 | N/A | (2) |
| MO2-stab2 | N/A | Stoll et al., 2013 |
| MO3-stab2 | N/A | Stoll et al., 2013 |
| MO4-stab2 | N/A | Rost et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C-type lectin fold | C-type lectin-like/link domain superfamily | EGF domain | EGF-like calcium-binding domain | EGF-like domain | FAS1 domain | FAS1 domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Laminin-type EGF domain | Link domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:C6GHV6 | InterPro | 2508 | ||||||||||
| UniProtKB:A0A8M9PUI5 | InterPro | 1703 | ||||||||||
| UniProtKB:F6P8Y7 | InterPro | 2543 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-129N6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-207J16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173591 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001290178 (1) | 7967 nt | ||
| Genomic | GenBank:CR383662 (2) | 174773 nt | ||
| Polypeptide | UniProtKB:F6P8Y7 (1) | 2543 aa |
- Zhou, W., Ghersi, J.J., Ristori, E., Semanchik, N., Prendergast, A., Zhang, R., Carneiro, P., Baldissera, G., Sessa, W.C., Nicoli, S. (2024) Akt is a mediator of artery specification during zebrafish development. Development (Cambridge, England). 151(17):
- Wang, Y.S., Chen, Y.T., Wu, C.Y. (2023) Functional characterization of stap2b in zebrafish vascular development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e23053e23053
- Li, R.F., Wang, Y.S., Lu, F.I., Huang, Y.S., Chiu, C.C., Tai, M.H., Wu, C.Y. (2022) Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Biomedicines. 10(6)
- Lo, Y.H., Huang, Y.S., Chang, Y.C., Hung, P.Y., Wang, W.D., Liu, W., Urade, R., Wen, Z.H., Wu, C.Y. (2022) GTP-Binding Protein 1-Like (GTPBP1l) Regulates Vascular Patterning during Zebrafish Development. Biomedicines. 10(12):
- Verwilligen, R.A.F., Mulder, L., Rodenburg, F.J., Van Dijke, A., Hoekstra, M., Bussmann, J., Van Eck, M. (2022) Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish. Atherosclerosis. 346:18-25
- Arias-Alpizar, G., Koch, B., Hamelmann, N.M., Neustrup, M.A., Paulusse, J.M.J., Jiskoot, W., Kros, A., Bussmann, J. (2021) Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles. Nanomedicine : nanotechnology, biology, and medicine. 34:102395
- Huisman, Y., Uphoff, K., Berger, M., Dobrindt, U., Schelhaas, M., Zobel, T., Bussmann, J., van Impel, A., Schulte-Merker, S. (2021) Meningeal lymphatic endothelial cells fulfill scavenger endothelial cell function and cooperate with microglia in waste removal from the brain. Glia. 70(1):35-49
- Metikala, S., Casie Chetty, S., Sumanas, S. (2021) Single-cell transcriptome analysis of the zebrafish embryonic trunk. PLoS One. 16:e0254024
- Saez Talens, V., Arias-Alpizar, G., Makurat, D.M.M., Davis, J., Bussmann, J., Kros, A., Kieltyka, R.E. (2020) Stab2-Mediated Clearance of Supramolecular Polymer Nanoparticles in Zebrafish Embryos. Biomacromolecules. 21(3):1060-1068
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
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