Gene
pax4
- ID
- ZDB-GENE-041210-244
- Name
- paired box 4
- Symbol
- pax4 Nomenclature History
- Previous Names
-
- DKEY-146J3.4 (1)
- si:dkey-146j3.3
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within endocrine pancreas development; glucose homeostasis; and pancreas regeneration. Predicted to be located in nucleus. Is expressed in endocrine system and gut. Human ortholog(s) of this gene implicated in diabetic ketoacidosis; maturity-onset diabetes of the young type 9; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human PAX4 (paired box 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-pax4 | N/A | Djiotsa et al., 2012 |
MO2-pax4 | N/A | Djiotsa et al., 2012 |
MO3-pax4 | N/A | O'Hare et al., 2016 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
diabetic ketoacidosis | Alliance | {Diabetes mellitus, ketosis-prone, susceptibility to} | 612227 |
maturity-onset diabetes of the young type 9 | Alliance | Maturity-onset diabetes of the young, type IX | 612225 |
type 2 diabetes mellitus | Alliance | Diabetes mellitus, type 2 | 125853 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Paired DNA-binding domain | Paired domain | PAX family | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:G2ZGB0 | InterPro | 360 | |||||||
UniProtKB:A0A8M9PHB0 | InterPro | 227 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-146J3 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001245080 (1) | 1293 nt | ||
Genomic | GenBank:BX897731 (1) | 99029 nt | ||
Polypeptide | UniProtKB:G2ZGB0 (1) | 360 aa |
- Fang, Y., Wan, J.P., Zhang, R.J., Sun, F., Yang, L., Zhao, S.X., Dong, M., Song, H.D. (2022) Tpo knockout in zebrafish partially recapitulates clinical manifestations of congenital hypothyroidism and reveals the involvement of TH in proper development of glucose homeostasis. General and comparative endocrinology. 323-324:114033
- Lavergne, A., Tarifeño-Saldivia, E., Pirson, J., Reuter, A.S., Flasse, L., Manfroid, I., Voz, M.L., Peers, B. (2020) Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. BMC Biology. 18:109
- Pak, B., Schmitt, C.E., Oh, S., Kim, J.D., Choi, W., Han, O., Kim, M., Kim, M.J., Ham, H.J., Kim, S., Huh, T.L., Kim, J.I., Jin, S.W. (2020) Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish. Biochemical and Biophysical Research Communications. 534:359-366
- Ravi, V., Bhatia, S., Shingate, P., Tay, B.H., Venkatesh, B., Kleinjan, D.A. (2019) Lampreys, the jawless vertebrates, contain three Pax6 genes with distinct expression in eye, brain and pancreas. Scientific Reports. 9:19559
- Matsuda, H., Mullapudi, S.T., Carol Yang, Y.H., Masaki, H., Hesselson, D., Stainier, D.Y.R. (2018) Whole Organism Chemical Screening Identifies Modulators of Pancreatic β Cell Function. Diabetes... 67(11):2268-2279
- Wagner, D.E., Weinreb, C., Collins, Z.M., Briggs, J.A., Megason, S.G., Klein, A.M. (2018) Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science (New York, N.Y.). 360(6392):981-987
- Beaver, L.M., Nkrumah-Elie, Y.M., Truong, L., Barton, C.L., Knecht, A.L., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model. The Journal of Nutritional Biochemistry. 43:78-87
- Matsuda, H., Mullapudi, S.T., Zhang, Y., Hesselson, D., Stainier, D.Y.R. (2017) Thyroid Hormone Coordinates Pancreatic Islet Maturation During the Zebrafish Larval to Juvenile Transition to Maintain Glucose Homeostasis. Diabetes... 66(10):2623-2635
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Feiner, N., Meyer, A., Kuraku, S. (2014) Evolution of the vertebrate Pax4/6 class of genes with focus on its novel member, the Pax10 gene. Genome biology and evolution. 6(7):1635-51
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