Gene

pax4

ID
ZDB-GENE-041210-244
Name
paired box 4
Symbol
pax4 Nomenclature History
Previous Names
  • DKEY-146J3.4 (1)
  • si:dkey-146j3.3
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within endocrine pancreas development; glucose homeostasis; and pancreas regeneration. Predicted to be located in nucleus. Is expressed in endocrine system and gut. Human ortholog(s) of this gene implicated in diabetic ketoacidosis; maturity-onset diabetes of the young type 9; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human PAX4 (paired box 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
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Human Disease
Associated With pax4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
diabetic ketoacidosis Alliance {Diabetes mellitus, ketosis-prone, susceptibility to} 612227
maturity-onset diabetes of the young type 9 Alliance Maturity-onset diabetes of the young, type IX 612225
type 2 diabetes mellitus Alliance Diabetes mellitus, type 2 125853
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Associated With pax4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR001523 Paired domain
Domain IPR043182 Paired DNA-binding domain
Family IPR043565 PAX family
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Domain Details Per Protein
Protein Additional Resources Length Homedomain-like superfamily Homeobox, conserved site Homeodomain Paired DNA-binding domain Paired domain PAX family Winged helix-like DNA-binding domain superfamily
UniProtKB:G2ZGB0 InterPro 360
UniProtKB:A0A8M9PHB0 InterPro 227
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 4
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pax4-201 (1) Ensembl 1,231 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-146J3ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPAX47
Conserved genome location (synteny) (2)
Phylogenetic tree (1)
Amino acid sequence comparison (4)
MousePax46
Conserved genome location (synteny) (1)
Amino acid sequence comparison (3)
Phylogenetic tree (1)
Citations
1 - 10 of 12
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