Gene
crhb
- ID
- ZDB-GENE-041114-75
- Name
- corticotropin releasing hormone b
- Symbol
- crhb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Acts upstream of or within several processes, including melanosome localization; regulation of hematopoietic stem cell differentiation; and response to immobilization stress. Predicted to be located in extracellular region. Is expressed in several structures, including brain; eye; gill; heart; and testis. Human ortholog(s) of this gene implicated in obesity and panic disorder. Orthologous to human CRH (corticotropin releasing hormone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 63 figures from 40 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct862 | Allele with one delins | Unknown | Unknown | CRISPR | |
| la014553Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022938Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nns75Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-crhb | (3) | |
| CRISPR2-crhb | Ma et al., 2023 | |
| MO1-crhb | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Corticotropin-releasing factor | Corticotropin-releasing factor conserved site | Urocortin/corticotropin-releasing factor |
|---|---|---|---|---|---|
| UniProtKB:Q5U3N6 | InterPro | 162 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(crhb:TagRFP) |
|
| 1 | Vom Berg-Maurer et al., 2016 | |
| Tg(crhb:GAL4) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-125L9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101864 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192053 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007379 (1) | 1096 nt | ||
| Genomic | GenBank:CR354424 (1) | 119245 nt | ||
| Polypeptide | UniProtKB:Q5U3N6 (1) | 162 aa |
- Espigares, F., Alvarado, M.V., Abad-Tortosa, D., Varela, S.A.M., Sobral, D., Faísca, P., Paixão, T., Oliveira, R.F. (2025) Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish. Translational psychiatry. 15:111111
- Castillo-Ramírez, L.A., Herget, U., Ryu, S., De Marco, R.J. (2024) Early-life challenge enhances cortisol regulation in zebrafish larvae. Biology Open. 13(12):
- Fagundes, T., Pannetier, P., Gölz, L., Behnstedt, L., Morthorst, J., Vergauwen, L., Knapen, D., Holbech, H., Braunbeck, T., Baumann, L. (2024) The generation gap in endocrine disruption: Can the integrated fish endocrine disruptor test (iFEDT) bridge the gap by assessing intergenerational effects of thyroid hormone system disruption?. Aquatic toxicology (Amsterdam, Netherlands). 272:106969106969
- Kim, T.Y., Roychaudhury, A., Kim, H.T., Choi, T.I., Baek, S.T., Thyme, S.B., Kim, C.H. (2024) Impairments of cerebellar structure and function in a zebrafish KO of neuropsychiatric risk gene znf536. Translational psychiatry. 14:8282
- Lee, A., Kim, S.Y., Kang, S., Kang, S.H., Kim, D.W., Choe, J.W., Hyun, J.J., Jung, S.W., Jung, Y.K., Koo, J.S., Yim, H.J., Kim, S. (2024) Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae. International Journal of Molecular Sciences. 25(7):
- Rajeswari, J.J., Faught, E., Santos, H., Vijayan, M.M. (2024) Mineralocorticoid receptor activates postnatal adiposity in zebrafish lacking proopiomelanocortin. Journal of Cellular Physiology. 239(12):e31428
- Raterman, S.T., Wagener, F.A.D.T.G., Zethof, J., Cuijpers, V., Klaren, P.H.M., Metz, J.R., Von den Hoff, J.W. (2024) foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Sagi, D., Tibi, M., Admati, I., Lerer-Goldshtein, T., Hochgerner, H., Zeisel, A., Appelbaum, L. (2024) Single-cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(36):
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Lin, C.Y., Yeh, K.Y., Lai, H.H., Her, G.M. (2023) AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish. Biomedicines. 11(2):
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