Gene
ace2
- ID
- ZDB-GENE-041114-6
- Name
- angiotensin I converting enzyme 2
- Symbol
- ace2 Nomenclature History
- Previous Names
-
- zgc:92514 (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable carboxypeptidase activity and metallopeptidase activity. Predicted to be involved in angiotensin maturation. Predicted to act upstream of or within proteolysis. Predicted to be located in several cellular components, including apical plasma membrane; cilium; and extracellular region. Predicted to be active in extracellular space and plasma membrane. Is expressed in brain; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb442 | Allele with one deletion | Exon 8 | Unknown | CRISPR | |
| ihb449 | Allele with one deletion | Exon 8 | Unknown | CRISPR | |
| sa1003 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10138 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41865 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ace2 | Zebrafish Nomenclature Committee | |
| CRISPR2-ace2 | Zebrafish Nomenclature Committee | |
| CRISPR3-ace2 | Tyrkalska et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Collectrin domain | Peptidase M2, peptidyl-dipeptidase A |
|---|---|---|---|---|
| UniProtKB:A0A8M2BGN5 | InterPro | 807 | ||
| UniProtKB:E7F9E5 | InterPro | 818 | ||
| UniProtKB:Q5U380 | InterPro | 785 | ||
| UniProtKB:A0AB32TXH6 | InterPro | 783 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-226L13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92514 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007297 (1) | 2881 nt | ||
| Genomic | GenBank:CU652893 (1) | 54988 nt | ||
| Polypeptide | UniProtKB:E7F9E5 (1) | 818 aa |
- Wang, T., Lin, X., Li, Y., Lu, Y. (2023) Artificial Lipid Biomembranes for Full-Length SARS-CoV-2 Receptor. Advanced materials (Deerfield Beach, Fla.). 35:e2300575e2300575
- Choi, S.S.A., Chan, H.H., Chan, C.M., Wang, X., Webb, S.E., Leung, K.W., Tsim, K.W.K., Miller, A.L. (2022) Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry. Journal of virology. 96(24):e0141822
- Kraus, A., Huertas, M., Ellis, L., Boudinot, P., Levraud, J.P., Salinas, I. (2022) Intranasal delivery of SARS-CoV-2 Spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish. Brain, behavior, and immunity. 102:341-359
- Tyrkalska, S.D., Martínez-López, A., Arroyo, A.B., Martínez-Morcillo, F.J., Candel, S., García-Moreno, D., Mesa-Del-Castillo, P., Cayuela, M.L., Mulero, V. (2022) Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern. Science advances. 8:eabo0732
- He, L., Chen, Y., Hu, Z., Zhang, Y., Wang, Y., Wei, J., Fan, Z., Xu, J., Peng, M., Zhao, K., Zhang, H., Liu, C. (2021) Evaluation of 3,4,4,9-trichlorocarbanilide to zebrafish developmental toxicity based on transcriptomics analysis. Chemosphere. 278:130349
- Kim, G.J., Melgoza, A., Jiang, F., Guo, S. (2021) The effect of renin-angiotensin-aldosterone system inhibitors on organ-specific ace2 expression in zebrafish and its implications for COVID-19. Scientific Reports. 11:23670
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Raby, L., Völkel, P., Hasanpour, S., Cicero, J., Toillon, R.A., Adriaenssens, E., Van Seuningen, I., Le Bourhis, X., Angrand, P.O. (2021) Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish. Cells. 10(11):
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
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