Gene
fosb
- ID
- ZDB-GENE-041114-181
- Name
- FBJ murine osteosarcoma viral oncogene homolog B
- Symbol
- fosb Nomenclature History
- Previous Names
-
- zgc:92354
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including brain; epidermis; germ ring; hatching gland; and post-vent region. Orthologous to human FOSB (FosB proto-oncogene, AP-1 transcription factor subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | AP-1 transcription factor | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily |
---|---|---|---|---|---|
UniProtKB:A0A8M2BL93 | InterPro | 352 | |||
UniProtKB:Q1LXX4 | InterPro | 411 | |||
UniProtKB:A0A2R8QTZ5 | InterPro | 356 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-160D20 | ZFIN Curated Data | |
Encodes | cDNA | MGC:92354 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001007312 (1) | 1920 nt | ||
Genomic | GenBank:BX248121 (2) | 201816 nt | ||
Polypeptide | UniProtKB:Q1LXX4 (1) | 411 aa |
- Guan, K., Ye, M., Guo, A., Chen, X., Shan, Y., Li, X. (2024) Deficiency of leap2 promotes somatic growth in zebrafish: Involvement of the growth hormone system. Heliyon. 10:e36397e36397
- Luo, H., Li, Q., Hong, J., Huang, Z., Deng, W., Wei, K., Lu, S., Wang, H., Zhang, W., Liu, W. (2024) Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842. Haematologica. 109(7):2092-2110
- Xie, B., Liang, J., Jiang, J., Zeng, T., Liu, L., Xie, D., Zhu, G., Xiong, L., Zhang, K., Liu, D., Gong, J., Chen, X., Lai, R., Xie, H. (2024) Zebrafish myo7aa affects congenital hearing by regulating Rho-GTPase signaling. Frontiers in molecular neuroscience. 17:14051091405109
- Zhou, X., Lian, K., Jia, J., Zhao, X., Duan, P., Huang, J., Shi, Y. (2024) Functions of Epimedin C in a zebrafish model of glucocorticoid-induced osteoporosis. Journal of Cellular and Molecular Medicine. 28:e18569e18569
- Maili, L., Tandon, B., Yuan, Q., Menezes, S., Chiu, F., Hashmi, S.S., Letra, A., Eisenhoffer, G.T., Hecht, J.T. (2023) Disruption of fos causes craniofacial anomalies in developing zebrafish. Frontiers in cell and developmental biology. 11:11418931141893
- Zuppo, D.A., Missinato, M.A., Santana-Santos, L., Li, G., Benos, P.V., Tsang, M. (2023) Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Development (Cambridge, England). 150(6):
- Kubra, K., Gaddu, G.K., Liongue, C., Heidary, S., Ward, A.C., Dhillon, A.S., Basheer, F. (2022) Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish. International Journal of Molecular Sciences. 23(17)
- Fan, E., Xu, Z., Yan, J., Wang, F., Sun, S., Zhang, Y., Zheng, S., Wang, X., Rao, Y. (2021) Acute exposure to N-Ethylpentylone induces developmental toxicity and dopaminergic receptor-regulated aberrances in zebrafish larvae. Toxicology and applied pharmacology. 417:115477
- Beisaw, A., Kuenne, C., Günther, S., Dallmann, J., Wu, C.C., Bentsen, M., Looso, M., Stainier, D. (2020) AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion during Zebrafish Heart Regeneration. Circulation research. 126(12):1760-1778
- Huang, W., Zheng, S., Xiao, J., Liu, C., Du, T., Wu, K. (2020) Parental exposure to bisphenol A affects pharyngeal cartilage development and causes global transcriptomic changes in zebrafish (Danio rerio) offspring. Chemosphere. 249:126537
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