Gene
tbc1d15
- ID
- ZDB-GENE-041111-251
- Name
- TBC1 domain family, member 15
- Symbol
- tbc1d15 Nomenclature History
- Previous Names
-
- im:7148793
- si:ch211-218c6.6
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to be located in cytoplasm. Is expressed in polster. Orthologous to human TBC1D15 (TBC1 domain family member 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148793 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013207Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020289Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13834 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14248 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43074 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Rab-GAP-TBC domain | Rab-GAP-TBC domain superfamily | Small G protein signalling modulator 1/2, Rab-binding domain |
|---|---|---|---|---|---|
| UniProtKB:A5PLG1 | InterPro | 359 | |||
| UniProtKB:A0A8M1NT23 | InterPro | 664 | |||
| UniProtKB:A0A8M2B5M9 | InterPro | 665 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tbc1d15-201
(1)
|
Ensembl | 2,356 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218C6 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7148793 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001172625 (1) | 2380 nt | ||
| Genomic | GenBank:BX323598 (1) | 197329 nt | ||
| Polypeptide | UniProtKB:A0A8M2B5M9 (1) | 665 aa |
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- Wang, Y., Liu, X., Xie, B., Yuan, H., Zhang, Y., Zhu, J. (2019) The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Redox Biology. 28:101313
- Xu, J., Li, Y., Lv, Y., Bian, C., You, X., Endoh, D., Teraoka, H., Shi, Q. (2019) Molecular Evolution of Tryptophan Hydroxylases in Vertebrates: A Comparative Genomic Survey. Genes. 10(3):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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