Gene
angptl4
- ID
- ZDB-GENE-041111-222
- Name
- angiopoietin-like 4
- Symbol
- angptl4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable enzyme inhibitor activity. Acts upstream of or within apoptotic process involved in blood vessel morphogenesis and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in endocrine pancreas; intestinal epithelium; intestine; and liver. Orthologous to human ANGPTL4 (angiopoietin like 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144703 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Serbanovic-Canic et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb725 | Allele with one deletion | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-angptl4 | Zebrafish Nomenclature Committee | |
| MO1-angptl4 | N/A | Serbanovic-Canic et al., 2017 |
| MO2-angptl4 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Plasma triglyceride level QTL, low | 615881 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020837 | Fibrinogen, conserved site |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Family | IPR037579 | Fibrinogen/angiopoietin-like |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen/angiopoietin-like | Fibrinogen, conserved site | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NYZ0 | InterPro | 460 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
angptl4-202
(1)
|
Ensembl | 2,397 nt | ||
| ncRNA |
angptl4-002
(1)
|
Ensembl | 224 nt | ||
| ncRNA |
angptl4-003
(1)
|
Ensembl | 492 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(-1angptl4:GFP) |
|
| 1 | (2) | |
| Tg1(-3.5angptl4:GFP) |
|
| 1 | (2) | |
| Tg1(-5.2angptl4:GFP) |
|
| 1 | (2) | |
| Tg(-1angptl4:GFP) |
|
| 1 | (2) | |
| Tg1(angptl4-Mmu.Fos:GFP) |
|
| 1 | (2) | |
| Tg1(angptl4-Mmu.Fos:TdTomato) |
|
| 1 | (2) | |
| Tg(-3.5angptl4:GFP) |
|
| 1 | (2) | |
| Tg3(angptl4-Mmu.Fos:GFP) |
|
| 1 | (3) | |
| Tg4(angptl4-Mmu.Fos:GFP) |
|
| 1 | (2) | |
| Tg(-5.2angptl4:GFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-39B20 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7144703 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256203 (1) | 2402 nt | ||
| Genomic | GenBank:BX530024 (1) | 146464 nt | ||
| Polypeptide | UniProtKB:A0A8M1NYZ0 (1) | 460 aa |
- Bowley, G., Irving, S., Hoefer, I., Wilkinson, R., Pasterkamp, G., Darwish, H.M.S., White, S., Francis, S.E., Chico, T., Noel, E., Serbanovic-Canic, J., Evans, P.C. (2024) Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Scientific Reports. 14:3013030130
- Alnassar, N., Hillman, C., Fontana, B.D., Robson, S.C., Norton, W.H.J., Parker, M.O. (2023) angptl4 gene expression as a marker of adaptive homeostatic response to social isolation across the lifespan in zebrafish. Neurobiology of aging. 131:209221209-221
- Guirgis, F.W., Jacob, V., Wu, D., Henson, M., Daly-Crews, K., Hopson, C., Black, L.P., DeVos, E.L., Sulaiman, D., Labilloy, G., Brusko, T.M., Shavit, J.A., Bertrand, A., Feldhammer, M., Baskovich, B., Graim, K., Datta, S., Reddy, S.T. (2023) DHCR7 Expression Predicts Porsusor Outcomes and Mortality From Sepsis. Critical care explorations. 5:e0929e0929
- Sun, W., Zhang, X., Qiao, Y., Griffin, N., Zhang, H., Wang, L., Liu, H. (2023) Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Ecotoxicology and environmental safety. 259:115020115020
- Wang, A., Wan, X., Zhuang, P., Jia, W., Ao, Y., Liu, X., Tian, Y., Zhu, L., Huang, Y., Yao, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Jiao, J., Zhang, Y. (2023) High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221097120e2221097120
- Chen, S., Ye, W., Clements, K.D., Zan, Z., Zhao, W., Zou, H., Wang, G., Wu, S. (2022) Bacillus licheniformis FA6 Affects Zebrafish Lipid Metabolism through Promoting Acetyl-CoA Synthesis and Inhibiting β-Oxidation. International Journal of Molecular Sciences. 24(1):
- Ogawa, Y., Corbo, J.C. (2021) Partitioning of gene expression among zebrafish photoreceptor subtypes. Scientific Reports. 11:17340
- Pottie, L., Van Gool, W., Vanhooydonck, M., Hanisch, F.G., Goeminne, G., Rajkovic, A., Coucke, P., Sips, P., Callewaert, B. (2021) Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures. PLoS Genetics. 17:e1009603
- Pereiro, P., Librán-Pérez, M., Figueras, A., Novoa, B. (2020) Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator. Developmental and comparative immunology. 109:103698
- Viana, J., Wildman, N., Hannon, E., Farbos, A., Neill, P.O., Moore, K., van Aerle, R., Paull, G., Santos, E., Mill, J. (2020) Clozapine-induced transcriptional changes in the zebrafish brain. NPJ schizophrenia. 6:3
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