Gene

tll1

ID
ZDB-GENE-041020-1
Name
tolloid-like 1
Symbol
tll1 Nomenclature History
Previous Names
  • tld (1)
  • mfn
  • mini fin
  • tolloid (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Enables metallopeptidase activity. Acts upstream of or within several processes, including determination of ventral identity; embryonic morphogenesis; and positive regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in cardiovascular system; hypural; margin; neural plate; and tail bud. Human ortholog(s) of this gene implicated in atrial heart septal defect 6; congenital heart disease; and coronary artery disease. Orthologous to human TLL1 (tolloid like 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
23 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la021034TgTransgenic insertionUnknownUnknownDNA
sa387Allele with one point mutationUnknownPremature StopENU
sa19476Allele with one point mutationUnknownPremature StopENU
tb241cAllele with one point mutationUnknownPremature StopENU
tc263aAllele with one point mutationUnknownUnknownENU
tf215aAllele with one point mutationUnknownPremature StopENU
tll1_unspecifiedUnspecified AlleleUnknownUnknownnot specified
tm124unknownUnknownUnknownENU
tm124aAllele with one point mutationUnknownPremature StopENU
tn217bAllele with one point mutationUnknownMissenseENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-tll1 (2)
MO1-tll1N/A (4)
MO2-tll1N/A (2)
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Human Disease
Associated With tll1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
atrial heart septal defect 6 Alliance Atrial septal defect 6 613087
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Associated With tll1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000859 CUB domain
Domain IPR001506 Peptidase M12A
Domain IPR001881 EGF-like calcium-binding domain
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Domain Details Per Protein
Protein Additional Resources Length Bone morphogenetic protein 1/tolloid-like protein CUB domain EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Metallopeptidase, catalytic domain superfamily Peptidase M12A Peptidase, metallopeptidase Spermadhesin, CUB domain superfamily Tolloid/BMP1 peptidase domain
UniProtKB:B3DJN6 InterPro 1022
UniProtKB:O57460 InterPro 1022
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tll1-201 (1) Ensembl 4,633 nt
mRNA tll1-202 (1) Ensembl 3,975 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(hsp70l:tll1)
  • tll1
  • Danio rerio
1 (2)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-198G9ZFIN Curated Data
Contained inBACDKEY-285B22ZFIN Curated Data
EncodescDNAMGC:195104ZFIN Curated Data
EncodescDNAMGC:195127ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTLL14
Conserved genome location (synteny) (2)
Amino acid sequence comparison (2)
Citations
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