Gene
tll1
- ID
- ZDB-GENE-041020-1
- Name
- tolloid-like 1
- Symbol
- tll1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables metallopeptidase activity. Acts upstream of or within several processes, including determination of ventral identity; embryonic morphogenesis; and positive regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in cardiovascular system; hypural; margin; neural plate; and tail bud. Human ortholog(s) of this gene implicated in atrial heart septal defect 6; congenital heart disease; and coronary artery disease. Orthologous to human TLL1 (tolloid like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la021034Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa387 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa19476 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
tb241c | Allele with one point mutation | Unknown | Premature Stop | ENU | |
tc263a | Allele with one point mutation | Unknown | Unknown | ENU | |
tf215a | Allele with one point mutation | Unknown | Premature Stop | ENU | |
tll1_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
tm124 | unknown | Unknown | Unknown | ENU | |
tm124a | Allele with one point mutation | Unknown | Premature Stop | ENU | |
tn217b | Allele with one point mutation | Unknown | Missense | ENU |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
atrial heart septal defect 6 | Alliance | Atrial septal defect 6 | 613087 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Bone morphogenetic protein 1/tolloid-like protein | CUB domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Metallopeptidase, catalytic domain superfamily | Peptidase M12A | Peptidase, metallopeptidase | Spermadhesin, CUB domain superfamily | Tolloid/BMP1 peptidase domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:B3DJN6 | InterPro | 1022 | |||||||||||
UniProtKB:O57460 | InterPro | 1022 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hsp70l:tll1) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-198G9 | ZFIN Curated Data | |
Contained in | BAC | DKEY-285B22 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195104 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195127 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131010 (1) | 4633 nt | ||
Genomic | GenBank:CR762472 (1) | 176472 nt | ||
Polypeptide | UniProtKB:B3DJN6 (1) | 1022 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Fu, S., Tan, R., Feng, Y., Yu, P., Mo, Y., Xiao, W., Wang, S., Zhang, J. (2022) N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway. Ecotoxicology and environmental safety. 239:113674
- Anderson, R.A., Schwalbach, K.T., Mui, S.R., LeClair, E.E., Topczewska, J.M., Topczewski, J. (2020) Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency. Disease models & mechanisms. 13(6):
- Carlantoni, C., Allanki, S., Kontarakis, Z., Rossi, A., Piesker, J., Günther, S., Stainier, D.Y.R. (2020) Tie1 regulates zebrafish cardiac morphogenesis through tolloid-like 1 expression. Developmental Biology. 469:54-67
- Tuazon, F.B., Wang, X., Andrade, J.L., Umulis, D., Mullins, M.C. (2020) Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation. Cell Reports. 32:108039
- Ghersi, J.J., Mahony, C.B., Bertrand, J.Y. (2019) bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish. Development (Cambridge, England). 146(6):
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Dasgupta, S., Cheng, V., Vliet, S.M.F., Mitchell, C.A., Volz, D.C. (2018) Tris(1,3-dichloro-2-propyl) phosphate Exposure During Early-Blastula Alters the Normal Trajectory of Zebrafish Embryogenesis. Environmental science & technology. 52(18):10820-10828
- Deng, C., Chen, H., Yang, N., Feng, Y., Hsueh, A.J. (2015) Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling. The Journal of biological chemistry. 290(30):18261-8
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
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