Gene
uts1
- ID
- ZDB-GENE-041014-348
- Name
- urotensin 1
- Symbol
- uts1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Predicted to be located in extracellular region. Is expressed in several structures, including basal plate midbrain region; heart; nervous system; pectoral fin; and testis. Orthologous to human UCN (urocortin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
uab445 | Allele with one deletion | Unknown | Unknown | CRISPR |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Corticotropin-releasing factor | Corticotropin-releasing factor conserved site | Urocortin/corticotropin-releasing factor |
---|---|---|---|---|---|
UniProtKB:Q5TZ50 | InterPro | 138 | |||
UniProtKB:A0A8M2B7S6 | InterPro | 250 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-243J20 | ZFIN Curated Data | |
Encodes | EST | fq17a01 | Rauch et al., 2003 | |
Encodes | cDNA | MGC:153826 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192115 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001030180 (1) | 1800 nt | ||
Genomic | GenBank:BX510372 (2) | 134837 nt | ||
Polypeptide | UniProtKB:A0A8M2B7S6 (1) | 250 aa |
- Westphal, M., Panza, P., Kastenhuber, E., Wehrle, J., Driever, W. (2022) Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish. Scientific Reports. 12:1030
- Kawabe, M., Hayashi, A., Komatsu, M., Inui, A., Shiozaki, K. (2021) Ninjinyoeito improves anxiety behavior in neuropeptide Y deficient zebrafish. Neuropeptides. 87:102136
- Mikloska, K.V., Zrini, Z.A., Bernier, N.J. (2021) Severe hypoxia exposure inhibits larval brain development but does not affect the capacity to mount a cortisol stress response in zebrafish. The Journal of experimental biology. 225(2)
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
- Chen, L., Wang, Y., Giesy, J.P., Chen, F., Shi, T., Chen, J., Xie, P. (2018) Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish. Environmental pollution (Barking, Essex : 1987). 241:540-548
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Williams, T.A., Bergstrome, J.C., Scott, J., Bernier, N.J. (2017) CRF and urocortin 3 protect the heart from hypoxia/reoxygenation-induced apoptosis in zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 313(2):R91-R100
- Williams, T.A., Bonham, L.A., Bernier, N.J. (2017) High environmental ammonia exposure has developmental-stage specific and long-term consequences on the cortisol stress response in zebrafish. General and comparative endocrinology. 254:97-106
- Cardoso, J.C., Bergqvist, C.A., Felix, R.C., Larhammar, D. (2016) Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages. Journal of molecular endocrinology. 57(1):73-86
- Grone, B.P., Maruska, K.P. (2015) Divergent evolution of two corticotropin-releasing hormone (CRH) genes in teleost fishes. Frontiers in neuroscience. 9:365
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