Gene
slc30a2
- ID
- ZDB-GENE-041014-347
- Name
- solute carrier family 30 member 2
- Symbol
- slc30a2 Nomenclature History
- Previous Names
-
- si:ch211-243j20.1
- ZnT2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in response to zinc ion and zinc ion transmembrane transport. Predicted to act upstream of or within zinc ion transport. Predicted to be located in bounding membrane of organelle; mitochondrial inner membrane; and neuron projection. Predicted to be active in plasma membrane. Is expressed in hindbrain; neurons; and spinal cord. Orthologous to human SLC30A2 (solute carrier family 30 member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1681 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la021624Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa23775 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa23776 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa43504 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Zinc deficiency, transient neonatal | 608118 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Cation Diffusion Facilitator/SLC30A | Cation efflux protein | Cation efflux protein, cytoplasmic domain superfamily | Cation efflux transmembrane domain superfamily |
---|---|---|---|---|---|---|
UniProtKB:A0A0R4IIM2 | InterPro | 336 | ||||
UniProtKB:F1QFA1 | InterPro | 398 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
slc30a2-201
(1)
|
Ensembl | 1,535 nt | ||
mRNA |
slc30a2-202
(1)
|
Ensembl | 1,180 nt | ||
mRNA |
slc30a2-203
(1)
|
Ensembl | 1,011 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-243J20 | ZFIN Curated Data | |
Contained in | BAC | CH211-245H14 | ZFIN Curated Data | |
Encodes | EST | eu1681 | Thisse et al., 2005 | |
Encodes | cDNA | MGC:194331 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001045020 (1) | 1011 nt | ||
Genomic | GenBank:BX569783 (2) | 200617 nt | ||
Polypeptide | UniProtKB:F1QFA1 (1) | 398 aa |
- Kong, N., Zhao, Q., Liu, C., Li, J., Liu, Z., Gao, L., Wang, L., Song, L. (2020) The involvement of zinc transporters in the zinc accumulation in the Pacific oyster Crassostrea gigas. Gene. 750:144759
- Zhao, L., Tan, J., Li, D., Jiang, L., Li, T., Yang, Y., Wang, G., Shang, Z., Wang, J., Zhou, J. (2019) SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish. Biochemical and Biophysical Research Communications. 511(4):896-902
- Beaver, L.M., Truong, L., Barton, C.L., Chase, T.T., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development. PLoS One. 12:e0183831
- Zheng, D., Feeney, G.P., Handy, R.D., Hogstrand, C., and Kille, P. (2014) Uptake epithelia behave in a cell-centric and not systems homeostatic manner in response to zinc depletion and supplementation. Metallomics : integrated biometal science. 6(1):154-65
- Krauss, J., Astrinidis, P., Frohnhöfer, H.G., Walderich, B., and Nüsslein-Volhard, C. (2013) transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival. Biology Open. 2(7):703-710
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Ho, E., Dukovcic, S., Hobson, B., Wong, C.P., Miller, G., Hardin, K., Traber, M.G., and Tanguay, R.L. (2012) Zinc transporter expression in zebrafish (Danio rerio) during development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 155(1):26-32
- Yan, G., Zhang, Y., Yu, J., Yu, Y., Zhang, F., Zhang, Z., Wu, A., Yan, X., Zhou, Y., and Wang, F. (2012) Slc39a7/zip7 Plays a Critical Role in Development and Zinc Homeostasis in Zebrafish. PLoS One. 7(8):e42939
- Zheng, D., Feeney, G.P., Kille, P., and Hogstrand, C. (2008) Regulation of ZIP and ZnT zinc transporters in zebrafish gill: zinc repression of ZIP10 transcription by an intronic MRE cluster. Physiological Genomics. 34(2):205-214
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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