Gene
ppp1r12a
- ID
- ZDB-GENE-041011-3
- Name
- protein phosphatase 1, regulatory subunit 12A
- Symbol
- ppp1r12a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Acts upstream of or within several processes, including actin filament bundle organization; convergent extension involved in axis elongation; and nervous system development. Located in cytoplasm. Is expressed in several structures, including digestive system; endoderm; mesoderm; myotome; and nervous system. Orthologous to several human genes including PPP1R12A (protein phosphatase 1 regulatory subunit 12A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 36 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2653Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la024489Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024490Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024491Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| p82emcf | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15933 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20271 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20272 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa25279 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sq181 | Allele with one point mutation | Unknown | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ppp1r12a | Cayuso et al., 2019 | |
| CRISPR2-ppp1r12a | Cayuso et al., 2019 | |
| CRISPR3-ppp1r12a | Cayuso et al., 2019 | |
| CRISPR4-ppp1r12a | Cayuso et al., 2019 | |
| CRISPR5-ppp1r12a | Cayuso et al., 2019 | |
| MO1-ppp1r12a | N/A | Huang et al., 2008 |
| MO2-ppp1r12a | N/A | (4) |
| MO3-ppp1r12a | N/A | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Genitourinary and/or/brain malformation syndrome | 618820 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR031775 | cGMP-dependent protein kinase, interacting domain |
| Family | IPR017401 | Protein phosphatase 1 regulatory subunit 12A/B/C |
| Family | IPR051226 | Protein Phosphatase 1 Regulatory Subunit |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | cGMP-dependent protein kinase, interacting domain | Protein Phosphatase 1 Regulatory Subunit | Protein phosphatase 1 regulatory subunit 12A/B/C |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PH66 | InterPro | 1065 | |||||
| UniProtKB:Q6DRG7 | InterPro | 1049 | |||||
| UniProtKB:A0A8M6YX05 | InterPro | 1081 | |||||
| UniProtKB:A0A8M9QB53 | InterPro | 1097 | |||||
| UniProtKB:A0A8M9PUD2 | InterPro | 1049 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppp1r12a-201
(1)
|
Ensembl | 4,846 nt | ||
| mRNA | ppp1r12a-tv201 (1) | 3,313 nt | |||
| mRNA | ppp1r12a-tv202 (1) | 3,032 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28J4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110448 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003870 (1) | 4745 nt | ||
| Genomic | GenBank:BX537286 (2) | 179930 nt | ||
| Polypeptide | UniProtKB:A0A8M9QB53 (1) | 1097 aa |
- Portolés, I., Ribera, J., Fernandez-Galán, E., Lecue, E., Casals, G., Melgar-Lesmes, P., Fernández-Varo, G., Boix, L., Sanduzzi, M., Aishwarya, V., Reig, M., Jiménez, W., Morales-Ruiz, M. (2024) Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice. International Journal of Molecular Sciences. 25(7):
- Qian, W., Yamaguchi, N., Lis, P., Cammer, M., Knaut, H. (2023) Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Current biology : CB. 34(2):245-259.e8
- Falat, E.J., Voit, G.C., Gutzman, J.H. (2022) Laminin-111 mutant studies reveal a hierarchy within laminin-111 genes in their requirement for basal epithelial tissue folding. Developmental Biology. 492:172-186
- Li, X., Liu, X., Xing, Y., Zeng, L., Liu, X., Shen, H., Ma, J. (2022) Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction. Investigative ophthalmology & visual science. 63:27
- Liu, X., Xing, Y., Liu, X., Zeng, L., Ma, J. (2022) Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin α2-I Domain-Collagen Complex Formation and RhoA/ROCK1 Signaling. Investigative ophthalmology & visual science. 63:13
- Bian, W.P., Pu, S.Y., Xie, S.L., Wang, C., Deng, S., Strauss, P.R., Pei, D.S. (2021) Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish. Cell death discovery. 7:250
- Peng, X., Feng, G., Zhang, Y., Sun, Y. (2021) PRC1 Stabilizes Cardiac Contraction by Regulating Cardiac Sarcomere Assembly and Cardiac Conduction System Construction. International Journal of Molecular Sciences. 22(21):
- Cayuso, J., Xu, Q., Addison, M., Wilkinson, D.G. (2019) Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness. eLIFE. 8:
- Dong, G., Huang, Y., Ding, H., Luo, L., Zhang, Y., Huang, H., Ruan, H. (2019) Mypt1 regulates Bmp signaling to promote embryonic exocrine pancreas growth in zebrafish. Genesis (New York, N.Y. : 2000). 58(2):e23345
- LaFlamme, A., Young, K.E., Lang, I., Weiser, D.C. (2018) Alternative splicing of (ppp1r12a/mypt1) in zebrafish produces a novel myosin phosphatase targeting subunit. Gene. 675:15-26
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