Gene
c1qc
- ID
- ZDB-GENE-041010-51
- Name
- complement component 1, q subcomponent, C chain
- Symbol
- c1qc Nomenclature History
- Previous Names
-
- zgc:103597
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Acts upstream of or within complement activation, classical pathway. Predicted to be located in extracellular region. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human C1QC (complement C1q C chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103597 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Pickart et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-c1qc | N/A | Pickart et al., 2006 |
| MO2-c1qc | N/A | Pickart et al., 2006 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| C1q deficiency 3 | 620322 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C1q domain | Collagen/C1q domain-containing | Collagen triple helix repeat | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q5XJ71 | InterPro | 214 | ||||
| UniProtKB:A0A8M1N299 | InterPro | 244 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-69C1 | ||
| Encodes | cDNA | MGC:103597 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191159 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001005976 (1) | 908 nt | ||
| Genomic | GenBank:BX510940 (1) | 172605 nt | ||
| Polypeptide | UniProtKB:A0A8M1N299 (1) | 244 aa |
- Demirci, Y., Cucun, G., Poyraz, Y.K., Mohammed, S., Heger, G., Papatheodorou, I., Ozhan, G. (2020) Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage. Frontiers in cell and developmental biology. 8:584604
- Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., Wen, Z. (2019) An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis. Developmental Cell. 49(4):605-617.e5
- Earley, A.M., Graves, C.L., Shiau, C.E. (2018) Critical Role for a Subset of Intestinal Macrophages in Shaping Gut Microbiota in Adult Zebrafish. Cell Reports. 25:424-436
- Ferrero, G., Mahony, C.B., Dupuis, E., Yvernogeau, L., Di Ruggiero, E., Miserocchi, M., Caron, M., Robin, C., Traver, D., Bertrand, J.Y., Wittamer, V. (2018) Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish. Cell Reports. 24:130-141
- Tran, M.T.N., Hamada, M., Jeon, H., Shiraishi, R., Asano, K., Hattori, M., Nakamura, M., Imamura, Y., Tsunakawa, Y., Fujii, R., Usui, T., Kulathunga, K., Andrea, C.S., Koshida, R., Kamei, R., Matsunaga, Y., Kobayashi, M., Oishi, H., Kudo, T., Takahashi, S. (2017) MafB is a critical regulator of complement component C1q. Nature communications. 8:1700
- Ren, L., Tan, X.J., Xiong, Y.F., Xu, K., Zhou, Y., Zhong, H., Liu, Y., Hong, Y., Liu, S.J. (2014) Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Gene. 552(2):265-71
- Veth, K.N., Willer, J.R., Collery, R.F., Gray, M.P., Willer, G.B., Wagner, D.S., Mullins, M.C., Udvadia, A.J., Smith, R.S., John, S.W., Gregg, R.G., and Link, B.A. (2011) Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma. PLoS Genetics. 7(2):e1001310
- Hu, Y.L., Pan, X.M., Xiang, L.X., and Shao, J.Z. (2010) Characterization of C1Q in teleosts: insight into the molecular and functional evolution of C1Q family and classical pathway. The Journal of biological chemistry. 285(37):28777-28786
- Mei, J., and Gui, J. (2008) Bioinformatic identification of genes encoding C1q-domain-containing proteins in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 35(1):17-24
- Skarie, J.M., and Link, B.A. (2008) The Primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress–response pathway. Human molecular genetics. 17(16):2474-2485
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