Gene
mogat2
- ID
- ZDB-GENE-041010-186
- Name
- monoacylglycerol O-acyltransferase 2
- Symbol
- mogat2 Nomenclature History
- Previous Names
-
- MGAT2 (1)
- wu:fb94h05
- zgc:101667
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable 2-acylglycerol O-acyltransferase activity and diacylglycerol O-acyltransferase activity. Acts upstream of or within response to yeast. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in intestinal bulb; intestine; and yolk syncytial layer. Orthologous to human MOGAT2 (monoacylglycerol O-acyltransferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101667 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR007130 | Diacylglycerol acyltransferase |
1 - 1 of 1
Domain Details Per Protein
| Protein | Additional Resources | Length | Diacylglycerol acyltransferase |
|---|---|---|---|
| UniProtKB:F1R0E7 | InterPro | 368 | |
| UniProtKB:F1QSW7 | InterPro | 252 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mogat2-201
(1)
|
Ensembl | 1,438 nt | ||
| mRNA |
mogat2-202
(1)
|
Ensembl | 1,639 nt | ||
| mRNA |
mogat2-205
(1)
|
Ensembl | 1,537 nt | ||
| ncRNA |
mogat2-003
(1)
|
Ensembl | 571 nt | ||
| ncRNA |
mogat2-004
(1)
|
Ensembl | 533 nt |
1 - 5 of 5
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-19N18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-147G3 | ZFIN Curated Data | |
| Encodes | EST | fb94h05 | ||
| Encodes | cDNA | MGC:101667 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192293 | ZFIN Curated Data |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001326700 (1) | 1639 nt | ||
| Genomic | GenBank:CR293504 (1) | 165086 nt | ||
| Polypeptide | UniProtKB:F1R0E7 (1) | 368 aa |
- Wilson, M.H., Hensley, M.R., Shen, M.C., Lu, H.Y., Quinlivan, V.H., Busch-Nentwich, E.M., Rawls, J.F., Farber, S.A. (2024) Zebrafish are resilient to the loss of major diacylglycerol acyltransferase enzymes. The Journal of biological chemistry. 300(12):107973
- Wang, X., Ma, Q., Chen, L., Wu, H., Chen, L.Q., Qiao, F., Luo, Y., Zhang, M.L., Du, Z.Y. (2022) Peroxisome proliferator-activated receptor gamma is essential for stress adaptation by maintaining lipid homeostasis in female fish. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1867(7):159162
- Zhao, Y., Cao, X., Fu, L., Gao, J. (2020) n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterol homeostasis in fish. Applied Microbiology and Biotechnology. 104(5):2149-2161
- Postlethwait, J.H., Navajas Acedo, J., Piotrowski, T. (2019) Evolutionary Origin and Nomenclature of Vertebrate Wnt11-Family Genes. Zebrafish. 16(5):469-476
- Pan, Y.X., Zhuo, M.Q., Li, D.D., Xu, Y.H., Wu, K., Luo, Z. (2018) SREBP-1 and LXRα pathways mediated Cu-induced hepatic lipid metabolism in zebrafish Danio rerio. Chemosphere. 215:370-379
- Sæle, Ø., Rød, K.E.L., Quinlivan, V.H., Li, S., Farber, S.A. (2018) A novel system to quantify intestinal lipid digestion and transport. Biochimica et biophysica acta. 1863(9):948-957
- Wang, Y.C., Lin, C., Chuang, M.T., Hsieh, W.P., Lan, C.Y., Chuang, Y.J., and Chen, B.S. (2013) Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. BMC systems biology. 7:79
- Holmes, R.S. (2010) Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT). Comparative biochemistry and physiology. Part D, Genomics & proteomics. 5(1):45-54
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 9 of 9
Show