Gene
cited2
- ID
- ZDB-GENE-041010-141
- Name
- Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
- Symbol
- cited2 Nomenclature History
- Previous Names
-
- zgc:103418
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable transcription coactivator activity. Predicted to act upstream of or within cell differentiation and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including brain; immature eye; lens; optic primordium; and pharyngeal arch. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in atrial heart septal defect 8 and ventricular septal defect. Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103418 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Santos et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cited2 | N/A | Santos et al., 2019 |
| MO2-cited2 | N/A | Santos et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| atrial heart septal defect 8 | Alliance | Atrial septal defect 8 | 614433 |
| ventricular septal defect | Alliance | Ventricular septal defect 2 | 614431 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital heart disease | AB + MO1-cited2 + MO2-cited2 | standard conditions | Santos et al., 2019 |
| congenital heart disease | AB + MO2-cited2 | standard conditions | Santos et al., 2019 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR007576 | CITED |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CITED |
|---|---|---|---|
| UniProtKB:Q5XJD6 | InterPro | 222 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cited2-201
(1)
|
Ensembl | 2,345 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-34F16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103418 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193027 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001006045 (1) | 2368 nt | ||
| Genomic | GenBank:BX248390 (1) | 239874 nt | ||
| Polypeptide | UniProtKB:Q5XJD6 (1) | 222 aa |
- Zhang, B., Zhu, Y., Tang, Y., Liu, L., Liu, Y., Li, Y., Yu, W., Lu, L. (2025) The mediator subunit complex protein MED15 promotes lipid deposition and cancer progression during hypoxia. The Journal of biological chemistry. :108296108296
- Liao, Q., Zhu, C., Sun, X., Wang, Z., Chen, X., Deng, H., Tang, J., Jia, S., Liu, W., Xiao, W., Liu, X. (2023) Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance. The Journal of biological chemistry. 299(8):105074
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
- Shimizu, T., Fujita, N., Tsuji-Tamura, K., Kitagawa, Y., Fujisawa, T., Tamura, M., Sato, M. (2021) Osteocytes as main responders to low-intensity pulsed ultrasound treatment during fracture healing. Scientific Reports. 11:10298
- Huang, Y., Jiang, B., Xia, Y., Wang, J., Ji, C., Tong, J., Chen, T., Jiang, Y. (2020) Downregulation of miR-133a contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish. Chemosphere. 251:126610
- Santos, J.M.A., Mendes-Silva, L., Afonso, V., Martins, G., Machado, R.S.R., Lopes, J.A., Cancela, L., Futschik, M.E., Sachinidis, A., Gavaia, P., Bragança, J. (2019) Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants. Cell Death & Disease. 10:582
- Kindt, L.M., Coughlin, A.R., Perosino, T.R., Ersfeld, H., Hampton, M., Liang, J.O. (2018) Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing. Genesis (New York, N.Y. : 2000). 56(3):e23096
- Xiao, W., Cai, X., Zhang, D., Wang, J., Liu, X., Ouyang, G. (2018) Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish.. The Journal of biological chemistry. 293(40):15370-15380
- Lin, S.J., Chiang, M.C., Shih, H.Y., Chiang, K.C., Cheng, Y.C. (2017) Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. Development genes and evolution. 227(3):219-230
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