Gene
polr2b
- ID
- ZDB-GENE-041008-1
- Name
- RNA polymerase II subunit B
- Symbol
- polr2b Nomenclature History
- Previous Names
-
- zgc:109952
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including metal ion binding activity; nucleotidyltransferase activity; and ribonucleoside binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to act upstream of or within DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Orthologous to human POLR2B (RNA polymerase II subunit B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109952 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2635Tg | Transgenic insertion | Exon 1 | Unknown | DNA | |
| la019094Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12802 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR007121 | RNA polymerase, beta subunit, conserved site |
| Domain | IPR007120 | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain |
| Domain | IPR007641 | RNA polymerase Rpb2, domain 7 |
| Domain | IPR007642 | RNA polymerase Rpb2, domain 2 |
| Domain | IPR007644 | RNA polymerase, beta subunit, protrusion |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DNA-directed RNA polymerase, subunit 2 | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily | RNA polymerase, beta subunit, conserved site | RNA polymerase, beta subunit, protrusion | RNA polymerase Rpb2, domain 2 | RNA polymerase Rpb2, domain 2 superfamily | RNA polymerase Rpb2, domain 3 | RNA polymerase Rpb2, domain 4 | RNA polymerase Rpb2, domain 5 | RNA polymerase Rpb2, domain 7 | RNA polymerase Rpb2, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1N6S0 | InterPro | 1174 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
polr2b-202
(1)
|
Ensembl | 1,345 nt | ||
| mRNA |
polr2b-203
(1)
|
Ensembl | 1,764 nt | ||
| mRNA |
polr2b-204
(1)
|
Ensembl | 6,508 nt | ||
| ncRNA |
polr2b-003
(1)
|
Ensembl | 360 nt | ||
| ncRNA |
polr2b-004
(1)
|
Ensembl | 823 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-273E20 | ||
| Encodes | cDNA | MGC:109952 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001024461 (1) | 3736 nt | ||
| Genomic | GenBank:AL954718 (1) | 125999 nt | ||
| Polypeptide | UniProtKB:A0A8M1N6S0 (1) | 1174 aa |
- Liu, S., Feng, Z., Su, M., Liu, C., Xi, Y., Chen, H., Luo, L., Tian, X., Zhao, F., Li, L. (2024) Tango6 regulates HSPC proliferation and definitive haematopoiesis via Ikzf1 and Cmyb in caudal haematopoietic tissue. Development (Cambridge, England). 152(1):
- Silva, I. A. L., Conceição, N., Michou, L., Cancela, M. L. (2014) Can zebrafish be a valid model to study Paget's disease of bone?. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 30(4):678-688
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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