Gene
nop10
- ID
- ZDB-GENE-041007-4
- Name
- NOP10 ribonucleoprotein homolog (yeast)
- Symbol
- nop10 Nomenclature History
- Previous Names
-
- nola3
- zgc:109956
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable telomerase RNA binding activity. Acts upstream of or within primitive hemopoiesis and rRNA processing. Predicted to be located in nucleolus. Predicted to be part of box H/ACA snoRNP complex and telomerase holoenzyme complex. Used to study dyskeratosis congenita. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 1. Orthologous to human NOP10 (NOP10 ribonucleoprotein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109956 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2578Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la025812Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11074 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive dyskeratosis congenita 1 | Alliance | ?Dyskeratosis congenita, autosomal recessive 1 | 224230 |
| ?Cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 2 | 620425 | ||
| ?Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 | 620400 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| dyskeratosis congenita | nop10hi2578Tg/hi2578Tg | standard conditions | Pereboom et al., 2011 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | H/ACA ribonucleoprotein complex, subunit Nop10 | H/ACA ribonucleoprotein complex, subunit Nop10 superfamily |
|---|---|---|---|---|
| UniProtKB:Q6DRH5 | InterPro | 64 | ||
| UniProtKB:A0A8M9Q7P7 | InterPro | 64 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | cDNA | MGC:109956 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003868 (1) | 609 nt | ||
| Genomic | GenBank:FO704874 (1) | 35451 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q7P7 (1) | 64 aa |
- Can, H., Chanumolu, S.K., Gonzalez-Muñoz, E., Prukudom, S., Otu, H.H., Cibelli, J.B. (2020) Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. BMC Genomics. 21:471
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Pereboom, T.C., Weele, L.J., Bondt, A., and Macinnes, A.W. (2011) A zebrafish model of dyskeratosis congenita reveals hematopoetic stem cell formation failure due to ribosomal protein-mediated p53 stabilization. Blood. 118(20):5458-65
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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