Gene
mybl2b
- ID
- ZDB-GENE-041007-1
- Name
- v-myb avian myeloblastosis viral oncogene homolog-like 2b
- Symbol
- mybl2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in mitotic cell cycle and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in blood; central nervous system; and heart. Orthologous to human MYBL2 (MYB proto-oncogene like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mybl2b | N/A | Shepard et al., 2005 |
| MO2-mybl2b | N/A | Shepard et al., 2005 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C-myb, C-terminal | Homedomain-like superfamily | Myb domain | SANT/Myb domain | Transcription factors Myb-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q4KMF7 | InterPro | 633 | |||||
| UniProtKB:A0AB32TZ83 | InterPro | 633 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mybl2b-201
(1)
|
Ensembl | 3,745 nt | ||
| mRNA |
mybl2b-202
(1)
|
Ensembl | 4,276 nt | ||
| mRNA |
mybl2b-203
(1)
|
Ensembl | 832 nt | ||
| mRNA |
mybl2b-204
(1)
|
Ensembl | 3,804 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-303B9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111798 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003867 (1) | 3816 nt | ||
| Genomic | GenBank:CU075911 (1) | 34507 nt | ||
| Polypeptide | UniProtKB:A0AB32TZ83 (1) | 633 aa |
- England, S.J., Campbell, P.C., Banerjee, S., Bates, R.L., Grieb, G., Fancher, W.F., Lewis, K.E. (2024) Transcriptional regulators with broad expression in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(11):1036-1055
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Chiarelli, N., Ritelli, M., Zoppi, N., Benini, A., Borsani, G., Barlati, S., and Colombi, M. (2011) Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene (slc2a10) in Danio rerio. The International journal of developmental biology. 55(2):229-36
- Sucularli, C., Senturk, S., Ozturk, M., and Konu, O. (2011) Dose- and time-dependent expression patterns of zebrafish orthologs of selected E2F target genes in response to serum starvation/replenishment. Molecular biology reports. 38(6):4111-23
- Sundström, G., Dreborg, S., and Larhammar, D. (2010) Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. PLoS One. 5(5):e10512
- Kleinschmidt, M.A., Wagner, T.U., Liedtke, D., Spahr, S., Samans, B., and Gaubatz, S. (2009) Lin9 is required for mitosis and cell survival during early zebrafish development. The Journal of biological chemistry. 284(19):13119-13127
- Neumann, J.C., Dovey, J.S., Chandler, G.L., Carbajal, L., and Amatruda, J.F. (2009) Identification of a heritable model of testicular germ cell tumor in the zebrafish. Zebrafish. 6(4):319-327
- Chen, J., Carney, S.A., Peterson, R.E., and Heideman, W. (2008) Comparative Genomics Identifies Genes Mediating Cardiotoxicity in the Embryonic Zebrafish Heart. Physiological Genomics. 33(2):148-158
- Goishi, K., Shimizu, A., Najarro, G., Watanabe, S., Rogers, R., Zon, L.I., and Klagsbrun, M. (2006) {alpha}A-crystallin expression prevents {gamma}-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens. Development (Cambridge, England). 133(13):2585-2593
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