Gene
foxf2b
- ID
- ZDB-GENE-041001-130
- Name
- forkhead box F2b
- Symbol
- foxf2b Nomenclature History
- Previous Names
-
- foxf2
- si:dkey-100f21.4
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within pericyte cell differentiation; tissue homeostasis; and vascular associated smooth muscle cell development. Predicted to be active in nucleus. Is expressed in head mesenchyme; pharyngeal arch 1; and pharyngeal arch 2. Orthologous to human FOXF2 (forkhead box F2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ca22 | Allele with one point mutation | Exon 1 | Frameshift, Premature Stop | TALEN | |
| ca23 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | TALEN | |
| el621 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb663 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| ihb674 | Allele with one delins | Exon 1 | Unknown | CRISPR | |
| sa37042 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-foxf2b | (2) | |
| CRISPR2-foxf2b | Zebrafish Nomenclature Committee | |
| TALEN1-foxf2b | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Family | IPR051770 | Forkhead box transcription regulator |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box transcription regulator | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FER3 | InterPro | 429 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxf2b-201
(1)
|
Ensembl | 2,027 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-100F21 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003200706 (1) | 2016 nt | ||
| Genomic | GenBank:BX510653 (1) | 90530 nt | ||
| Polypeptide | UniProtKB:E7FER3 (1) | 429 aa |
- Ferre-Fernández, J.J., Muheisen, S., Thompson, S., Semina, E.V. (2022) CRISPR-Cas9-mediated functional dissection of the foxc1 genomic region in zebrafish identifies critical conserved cis-regulatory elements. Human genomics. 16:49
- Ryu, J.R., Ahuja, S., Arnold, C.R., Potts, K.G., Mishra, A., Yang, Q., Sargurupremraj, M., Mahoney, D.J., Seshadri, S., Debette, S., Childs, S.J. (2022) Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer. Proceedings of the National Academy of Sciences of the United States of America. 119:e2121333119
- Chrystal, P.W., French, C.R., Jean, F., Havrylov, S., van Baarle, S., Peturson, A.M., Xu, P., Crump, J.G., Pilgrim, D.B., Lehmann, O.J., Waskiewicz, A.J. (2021) The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning. Genes. 12(2):
- Tarashansky, A.J., Musser, J.M., Khariton, M., Li, P., Arendt, D., Quake, S.R., Wang, B. (2021) Mapping single-cell atlases throughout Metazoa unravels cell type evolution. eLIFE. 10:
- Oralová, V., Rosa, J.T., Larionova, D., Witten, P.E., Huysseune, A. (2020) Multiple epithelia are required to develop teeth deep inside the pharynx. Proceedings of the National Academy of Sciences of the United States of America. 117(21):11503-11512
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
- Xu, P., Balczerski, B., Ciozda, A., Louie, K., Oralova, V., Huysseune, A., Crump, J.G. (2018) Fox proteins are modular competency factors for facial cartilage and tooth specification. Development (Cambridge, England). 145(12)
- Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Stroke Genetics Network (SiGN), International Stroke Genetics Consortium (ISGC) (2016) Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. The Lancet. Neurology. 15(7):695-707
- Arnold, C.R., Lamont, R.E., Walker, J.T., Spice, P.J., Chan, C.K., Ho, C.Y., Childs, S.J. (2015) Comparative analysis of genes regulated by Dzip1/iguana and Hedgehog in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(2):211-23
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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