Gene
prmt6
- ID
- ZDB-GENE-040914-7
- Name
- protein arginine methyltransferase 6
- Symbol
- prmt6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable histone binding activity and protein-arginine N-methyltransferase activity. Predicted to be involved in chromatin remodeling; negative regulation of DNA-templated transcription; and negative regulation of ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within DNA repair; chromatin organization; and peptidyl-arginine methylation. Predicted to be located in nucleus. Orthologous to human PRMT6 (protein arginine methyltransferase 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908706 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa44163 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-prmt6 | Charlton-Perkins et al., 2019 | |
| CRISPR2-prmt6 | Charlton-Perkins et al., 2019 | |
| MO1-prmt6 | N/A | (2) |
| MO2-prmt6 | N/A | Zhao et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein arginine N-methyltransferase | Protein arginine N-methyltransferase domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|
| UniProtKB:F1QC81 | InterPro | 355 | |||
| UniProtKB:Q6NWG4 | InterPro | 349 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Zhao, X.X., Zhang, Y.B., Ni, P.L., Wu, Z.L., Yan, Y.C., Li, Y.P. (2016) Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45αa Stress Sensor Gene. The Journal of biological chemistry. 291(1):402-12
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Dong, C.W., Zhang, Y.B., Lu, A.J., Zhu, R., Zhang, F.T., Zhang, Q.Y., and Gui, J.F. (2007) Molecular characterisation and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection. Fish & shellfish immunology. 22(4):380-393
- Hung, C.M., and Li, C. (2004) Identification and phylogenetic analyses of the protein arginine methyltransferase gene family in fish and ascidians. Gene. 340(2):179-187
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