Gene
hmox2a
- ID
- ZDB-GENE-040914-13
- Name
- heme oxygenase 2a
- Symbol
- hmox2a Nomenclature History
- Previous Names
-
- im:6909100
- si:dkey-44g23.7 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and heme oxygenase (decyclizing) activity. Predicted to be involved in heme catabolic process; heme oxidation; and response to oxidative stress. Predicted to be located in membrane. Is expressed in brain; gill; and liver. Orthologous to human HMOX2 (heme oxygenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909100 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Luo et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hmox2a | Luo et al., 2021 | |
| CRISPR2-hmox2a | Luo et al., 2021 | |
| CRISPR3-hmox2a | Luo et al., 2021 | |
| CRISPR4-hmox2a | Luo et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Haem oxygenase | Haem oxygenase-like | Haem oxygenase-like, multi-helical |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9PJF2 | InterPro | 158 | |||
| UniProtKB:A7MD59 | InterPro | 310 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hmox2a-202
(1)
|
Ensembl | 826 nt | ||
| mRNA |
hmox2a-203
(1)
|
Ensembl | 6,194 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-44G23 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6909100 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:162585 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001103139 (1) | 1582 nt | ||
| Genomic | GenBank:AL953841 (1) | 219929 nt | ||
| Polypeptide | UniProtKB:A7MD59 (1) | 310 aa |
- Wang, H., Siren, J., Perttunen, S., Immonen, K., Chen, Y.C., Narumanchi, S., Kosonen, R., Paavola, J., Laine, M., Tikkanen, I., Lakkisto, P. (2024) Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Journal of Cellular and Molecular Medicine. 28:e18243e18243
- Wu, Y., Liu, W., Li, L., Tai, Z., Gao, B., Liu, J.X. (2023) Atp7b deficiency induces zebrafish eye developmental defects. Metallomics : integrated biometal science. 15(5):
- Luo, K., Ogawa, M., Ayer, A., Britton, W.J., Stocker, R., Kikuchi, K., Oehlers, S.H. (2022) Zebrafish Heme Oxygenase 1a Is Necessary for Normal Development and Macrophage Migration. Zebrafish. 19(1):7-17
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Luo, K., Stocker, R., Britton, W.J., Kikuchi, K., Oehlers, S.H. (2021) Heme oxygenase limits Mycobacterium marinum infection-induced detrimental ferrostatin-sensitive cell death in zebrafish. The FEBS journal. 289(3):671-681
- Zhao, G., Sun, H., Zhang, T., Liu, J.X. (2020) Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis. Cell communication and signaling : CCS. 18:45
- Lian, J., Chen, J., Wang, K., Zhao, L., Meng, P., Yang, L., Wei, J., Ma, N., Xu, J., Zhang, W., Zhang, Y. (2018) Alas1 is essential for neutrophil maturation in zebrafish. Haematologica. 103(11):1785-1795
- Zhang, Y., Ding, Z., Zhao, G., Zhang, T., Xu, Q., Cui, B., Liu, J.X. (2018) Transcriptional responses and mechanisms of copper nanoparticle toxicology on zebrafish embryos. Journal of hazardous materials. 344:1057-1068
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Holowiecki, A., O'Shields, B., Jenny, M.J. (2016) Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures. Toxicology and applied pharmacology. 311:74-87
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