Gene
pvalb6
- ID
- ZDB-GENE-040912-95
- Name
- parvalbumin 6
- Symbol
- pvalb6 Nomenclature History
- Previous Names
-
- zgc:103753
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to be active in cytoplasm. Is expressed in nervous system and otic vesicle. Orthologous to human PVALB (parvalbumin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103753 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa15691 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Parvalbumin |
|---|---|---|---|---|---|---|
| UniProtKB:Q804W1 | InterPro | 109 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pvalb6-201
(1)
|
Ensembl | 1,024 nt | ||
| mRNA |
pvalb6-202
(1)
|
Ensembl | 904 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(pvalb6:KALTA4) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260M3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-110G7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-217P22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103753 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192089 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205573 (1) | 1028 nt | ||
| Genomic | GenBank:CR812472 (1) | 194804 nt | ||
| Polypeptide | UniProtKB:Q804W1 (1) | 109 aa |
- Duan, W., Huang, G., Sui, Y., Wang, K., Yu, Y., Chu, X., Cao, X., Chen, L., Liu, J., Eichler, E.E., Xiong, B. (2024) Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 121:e2404173121e2404173121
- Prendergast, A.E., Jim, K.K., Marnas, H., Desban, L., Quan, F.B., Djenoune, L., Laghi, V., Hocquemiller, A., Lunsford, E.T., Roussel, J., Keiser, L., Lejeune, F.X., Dhanasekar, M., Bardet, P.L., Levraud, J.P., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Wyart, C. (2023) CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current biology : CB. 33(5):940-956.e10
- Ahi, E.P., Tsakoumis, E., Brunel, M., Schmitz, M. (2021) Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Fish physiology and biochemistry. 47(4):1283-1298
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Antinucci, P., Folgueira, M., Bianco, I.H. (2019) Pretectal neurons control hunting behaviour. eLIFE. 8:
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Modrell, M.S., Lyne, M., Carr, A.R., Zakon, H.H., Buckley, D., Campbell, A.S., Davis, M.C., Micklem, G., Baker, C.V. (2017) Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome. eLIFE. 6
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Di Donato, V., De Santis, F., Auer, T., Testa, N., Sánchez-Iranzo, H., Mercader, N., Concordet, J.P., Del Bene, F. (2016) 2C-Cas9: a versatile tool for clonal analysis of gene function. Genome research. 26(5):681-92
- Nolte, H., Konzer, A., Ruhs, A., Jungblut, B., Braun, T., Krüger, M. (2014) Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes. Journal of Proteome Research. 13:2162-74
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