Gene
gpx1b
- ID
- ZDB-GENE-040912-60
- Name
- glutathione peroxidase 1b
- Symbol
- gpx1b Nomenclature History
- Previous Names
-
- wu:fd42f12
- wu:fj22d06
- zgc:101700
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable glutathione peroxidase activity. Predicted to be involved in several processes, including hydrogen peroxide catabolic process; response to hydrogen peroxide; and response to selenium ion. Predicted to be active in cytosol and mitochondrion. Is expressed in digestive system; otic vesicle; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Orthologous to human GPX1 (glutathione peroxidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101700 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa18337 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hemolytic anemia due to glutathione peroxidase deficiency | 614164 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione peroxidase | Glutathione peroxidase active site | Thioredoxin-like superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8M1N295 | InterPro | 190 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-178O3 | ZFIN Curated Data | |
| Encodes | EST | fd42f12 | Woods et al., 2005 | |
| Encodes | EST | fj22d06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101700 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191621 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004634 (1) | 892 nt | ||
| Genomic | GenBank:BX957236 (2) | 211391 nt | ||
| Polypeptide | UniProtKB:A0A8M1N295 (1) | 190 aa |
- Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Xu, H., Mao, X., Nie, Z., Li, Y. (2023) Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish. Free radical biology & medicine. 203:102-113
- Chen, K., Wang, P., Chen, J., Ying, Y., Chen, Y., Gilson, E., Lu, Y., Ye, J. (2022) Loss of atm in Zebrafish as a Model of Ataxia-Telangiectasia Syndrome. Biomedicines. 10(2):
- Sun, S., Cao, X., Gao, J. (2021) C24:0 avoids cold exposure-induced oxidative stress and fatty acid β-oxidation damage. iScience. 24:103409
- Xu, H., Wang, G., Chi, Y.Y., Kou, Y.X., Li, Y. (2021) Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 39:100857
- Xu, H., Jiang, Y., Li, S., Xie, L., Tao, Y.X., Li, Y. (2020) Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging. Genes. 11(10):
- Kim, H., Ji, K. (2019) Exposure to humidifier disinfectants induces developmental effects and disrupts thyroid endocrine systems in zebrafish larvae. Ecotoxicology and environmental safety. 184:109663
- Lacave, J.M., Bilbao, E., Gilliland, D., Mura, F., Dini, L., Cajaraville, M.P., Orbea, A. (2019) Bioaccumulation, cellular and molecular effects in adult zebrafish after exposure to cadmium sulphide nanoparticles and to ionic cadmium. Chemosphere. 238:124588
- Rissone, A., Jimenez, E., Bishop, K., Carrington, B., Slevin, C., Wincovitch, S.M., Sood, R., Candotti, F., Burgess, S.M. (2019) A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress. Disease models & mechanisms. 12(12):
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