Gene

furinb

ID
ZDB-GENE-040901-2
Name
furin (paired basic amino acid cleaving enzyme) b
Symbol
furinb Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within cartilage development and intrahepatic bile duct development. Predicted to be located in endomembrane system and membrane. Predicted to be active in Golgi membrane and trans-Golgi network. Is expressed in several structures, including endoderm; eye; integument; liver; and pleuroperitoneal region. Orthologous to human FURIN (furin, paired basic amino acid cleaving enzyme).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ci207Allele with one deletionExon 2UnknownCRISPR
s741Allele with one point mutationUnknownUnknownnot specified
sa14482Allele with one point mutationUnknownPremature StopENU
sa39474Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-furinbEllis et al., 2022
MO1-furinbN/A (2)
MO2-furinbN/A (2)
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Human Disease
Associated With furinb Human Ortholog
No data available
Associated With furinb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR022398 Peptidase S8, subtilisin, His-active site
Active_site IPR023827 Peptidase S8, subtilisin, Asp-active site
Active_site IPR023828 Peptidase S8, subtilisin, Ser-active site
Domain IPR000209 Peptidase S8/S53 domain
Domain IPR002884 P domain
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Domain Details Per Protein
Protein Additional Resources Length Furin-like repeat Galactose-binding-like domain superfamily Growth factor receptor cysteine-rich domain superfamily Kexin/furin catalytic domain P domain Peptidase S8, pro-domain Peptidase S8, pro-domain superfamily Peptidase S8/S53 domain Peptidase S8/S53 domain superfamily Peptidase S8, subtilisin, Asp-active site Peptidase S8, subtilisin, His-active site Peptidase S8, subtilisin-related Peptidase S8, subtilisin, Ser-active site
UniProtKB:F1QKU2 InterPro 823
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA furinb-201 (1) Ensembl 3,427 nt
mRNA furinb-202 (1) Ensembl 897 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-256A21ZFIN Curated Data
Contained inBACCH211-256J21ZFIN Curated Data
Contained inBACDKEY-161L12ZFIN Curated Data
Contained inBACXX-BY172G11Anderson et al., 2008
EncodescDNAMGC:171328ZFIN Curated Data
EncodescDNAMGC:194537ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanFURIN15
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseFurin7
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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