Gene
furinb
- ID
- ZDB-GENE-040901-2
- Name
- furin (paired basic amino acid cleaving enzyme) b
- Symbol
- furinb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within cartilage development and intrahepatic bile duct development. Predicted to be located in endomembrane system and membrane. Predicted to be active in Golgi membrane and trans-Golgi network. Is expressed in several structures, including endoderm; eye; integument; liver; and pleuroperitoneal region. Orthologous to human FURIN (furin, paired basic amino acid cleaving enzyme).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-furinb | Ellis et al., 2022 | |
| MO1-furinb | N/A | (2) |
| MO2-furinb | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR022398 | Peptidase S8, subtilisin, His-active site |
| Active_site | IPR023827 | Peptidase S8, subtilisin, Asp-active site |
| Active_site | IPR023828 | Peptidase S8, subtilisin, Ser-active site |
| Domain | IPR000209 | Peptidase S8/S53 domain |
| Domain | IPR002884 | P domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Furin-like repeat | Galactose-binding-like domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Kexin/furin catalytic domain | P domain | Peptidase S8, pro-domain | Peptidase S8, pro-domain superfamily | Peptidase S8/S53 domain | Peptidase S8/S53 domain superfamily | Peptidase S8, subtilisin, Asp-active site | Peptidase S8, subtilisin, His-active site | Peptidase S8, subtilisin-related | Peptidase S8, subtilisin, Ser-active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QKU2 | InterPro | 823 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
furinb-201
(1)
|
Ensembl | 3,427 nt | ||
| mRNA |
furinb-202
(1)
|
Ensembl | 897 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-256A21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-256J21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-161L12 | ZFIN Curated Data | |
| Contained in | BAC | XX-BY172G11 | Anderson et al., 2008 | |
| Encodes | cDNA | MGC:171328 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194537 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045109 (1) | 3181 nt | ||
| Genomic | GenBank:CR407564 (1) | 180337 nt | ||
| Polypeptide | UniProtKB:F1QKU2 (1) | 823 aa |
- Hong, Y., Hu, C.B., Bai, J., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2023) Essential role of an ERV-derived Env38 protein in adaptive humoral immunity against an exogenous SVCV infection in a zebrafish model. PLoS pathogens. 19:e1011222e1011222
- Lessey, A.J., Mirczuk, S.M., Chand, A.N., Kurrasch, D.M., Korbonits, M., Niessen, S.J.M., McArdle, C.A., McGonnell, I.M., Fowkes, R.C. (2023) Pharmacological and Genetic Disruption of C-Type Natriuretic Peptide (nppcl) Expression in Zebrafish (Danio rerio) Causes Stunted Growth during Development. International Journal of Molecular Sciences. 24(16):
- Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097
- Klaver, E.J., Dukes-Rimsky, L., Kumar, B., Xia, Z.J., Dang, T., Lehrman, M.A., Angel, P., Drake, R.R., Freeze, H.H., Steet, R., Flanagan-Steet, H. (2021) Protease-dependent defects in N-cadherin processing drive PMM2-CDG pathogenesis. JCI insight. 6(24):
- Zhou, Q., Lei, L., Zhang, H., Chiu, S.C., Gao, L., Yang, R., Wei, W., Peng, G., Zhu, X., Xiong, J.W. (2021) Proprotein Convertase Furina Is Required for Heart Development in Zebrafish. Journal of Cell Science. 134(21):
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ojanen, M.J., Turpeinen, H., Cordova, Z.M., Hammarén, M.M., Harjula, S.K., Parikka, M., Rämet, M., Pesu, M. (2015) The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum. Infection and Immunity. 83(4):1431-42
- Anderson, R.M., Delous, M., Bosch, J.A., Ye, L., Robertson, M.A., Hesselson, D., and Stainier, D.Y. (2013) Hepatocyte Growth Factor Signaling in Intrapancreatic Ductal Cells Drives Pancreatic Morphogenesis. PLoS Genetics. 9(7):e1003650
- Turpeinen, H., Oksanen, A., Kivinen, V., Kukkurainen, S., Uusimaki, A., Ramet, M., Parikka, M., Hytonen, V.P., Nykter, M., and Pesu, M. (2013) Proprotein Convertase Subtilisin/Kexin Type 7 (PCSK7) Is Essential for the Zebrafish Development and Bioavailability of Transforming Growth Factor β1a (TGFβ1a). The Journal of biological chemistry. 288(51):36610-23
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