Gene
trpc5a
- ID
- ZDB-GENE-040812-1
- Name
- transient receptor potential cation channel, subfamily C, member 5a
- Symbol
- trpc5a Nomenclature History
- Previous Names
-
- trpc5
- wu:fi73f08
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in head; integument; and nervous system. Orthologous to human TRPC5 (transient receptor potential cation channel subfamily C member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa3325 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa5799 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19436 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32603 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32604 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko224a | Allele with one insertion | Unknown | Unknown | CRISPR | |
| zko224b | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013555 | Transient receptor ion channel domain |
| Family | IPR002153 | Transient receptor potential channel, canonical |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Ion transport domain | Transient receptor ion channel domain | Transient receptor potential channel, canonical |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q1MT28 | InterPro | 570 | |||||
| UniProtKB:A0A8M3AXK0 | InterPro | 1041 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trpc5a-201
(1)
|
Ensembl | 3,222 nt | ||
| mRNA |
trpc5a-202
(1)
|
Ensembl | 3,438 nt | ||
| mRNA |
trpc5a-204
(1)
|
Ensembl | 2,395 nt | ||
| mRNA |
trpc5a-205
(1)
|
Ensembl | 3,923 nt | ||
| mRNA |
trpc5a-206
(1)
|
Ensembl | 3,991 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31E10 | ZFIN Curated Data | |
| Encodes | EST | fi73f08 | ||
| Encodes | EST | IMAGE:2643303 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327747 (1) | 3923 nt | ||
| Genomic | GenBank:AL953910 (2) | 190793 nt | ||
| Polypeptide | UniProtKB:A0A8M3AXK0 (1) | 1041 aa |
- You, M.S., Yang, W.B., Cheng, C.H., Yu, S., Chang, H.C., Yu, H.S. (2020) Red LED light treatment promotes cognitive learning through up-regulation of trpm4 in zebrafish. Journal of photochemistry and photobiology. B, Biology. 213:112073
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Graham, D.M., Huang, L., Robinson, K.R., and Messerli, M.A. (2013) Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1. Journal of Cell Science. 126(Pt 20):4602-13
- von Niederhäusern, V., Kastenhuber, E., Stäuble, A., Gesemann, M., and Neuhauss, S.C. (2013) Phylogeny and expression of canonical transient receptor potential (TRPC) genes in developing zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(12):1427-41
- Petko, J.A., Kabbani, N., Frey, C., Woll, M., Hickey, K., Craig, M., Canfield, V.A., and Levenson, R. (2009) Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish. BMC Neuroscience. 10:27
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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