Gene
atm
- ID
- ZDB-GENE-040809-1
- Name
- ATM serine/threonine kinase
- Symbol
- atm Nomenclature History
- Previous Names
-
- chunp9624
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables kinase activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; regulation of cell cycle phase transition; and swimming behavior. Predicted to be located in centrosome; nucleoplasm; and peroxisome. Predicted to be active in chromosome; cytoplasm; and nucleus. Is expressed in brain; caudal fin; immature eye; and post-vent region. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Chen et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019487Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nya2 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| sa6364 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14977 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15974 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17959 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22587 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24975 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa28405 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35807 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-atm | Chen et al., 2022 | |
| CRISPR2-atm | Ying et al., 2022 | |
| CRISPR3-atm | Shin et al., 2021 | |
| CRISPR4-atm | Ajouaou et al., 2023 | |
| MO1-atm | N/A | (5) |
| TALEN1-atm | Thomas et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ataxia telangiectasia | Alliance | Ataxia-telangiectasia | 208900 |
| breast cancer | Alliance | {Breast cancer, susceptibility to} | 114480 |
| Lymphoma, B-cell non-Hodgkin, somatic | |||
| Lymphoma, mantle cell, somatic | |||
| T-cell prolymphocytic leukemia, somatic |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| ataxia telangiectasia | atmzf3863/zf3863 (TU) | standard conditions | Chen et al., 2022 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ATM, catalytic domain | FATC domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | PIK-related kinase | PIK-related kinase, FAT | Protein kinase-like domain superfamily | Serine/threonine-protein kinase ATM, plant | Telomere-length maintenance and DNA damage repair |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QJB6 | InterPro | 3091 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-121F8 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-349P20 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-449D16 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-598C2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002664557 (1) | 9856 nt | ||
| Genomic | GenBank:CU655855 (2) | 36037 nt | ||
| Polypeptide | UniProtKB:F1QJB6 (1) | 3091 aa |
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Ajouaou, Y., Magnani, E., Madakashira, B., Jenkins, E., Sadler, K.C. (2023) atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers. Cancers. 15(8):
- Boos, A., Gahr, B.M., Park, D.D., Braun, V., Bühler, A., Rottbauer, W., Just, S. (2023) Hdac1-deficiency affects the cell cycle axis Cdc25-Cdk1 causing impaired G2/M phase progression and reduced cardiomyocyte proliferation in zebrafish. Biochemical and Biophysical Research Communications. 665:9810698-106
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Babu, S., Takeuchi, Y., Masai, I. (2022) Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina. eLIFE. 11
- Chen, K., Wang, P., Chen, J., Ying, Y., Chen, Y., Gilson, E., Lu, Y., Ye, J. (2022) Loss of atm in Zebrafish as a Model of Ataxia-Telangiectasia Syndrome. Biomedicines. 10(2):
- Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
- Vierstraete, J., Fieuws, C., Creytens, D., Van Dorpe, J., Willaert, A., Vral, A., Claes, K.B. (2022) Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility. Genes & diseases. 10:381384381-384
- Ying, Y., Hu, X., Han, P., Mendez-Bermudez, A., Bauwens, S., Eid, R., Tan, L., Pousse, M., Giraud-Panis, M.J., Lu, Y., Gilson, E., Ye, J. (2022) The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Nucleic acids research. 50(4):2081-2095
- Li, X., Song, G., Zhao, Y., Ren, J., Li, Q., Cui, Z. (2021) Functions of SMC2 in the Development of Zebrafish Liver. Biomedicines. 9(9):
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