Gene

atm

ID
ZDB-GENE-040809-1
Name
ATM serine/threonine kinase
Symbol
atm Nomenclature History
Previous Names
  • chunp9624
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Enables kinase activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; regulation of cell cycle phase transition; and swimming behavior. Predicted to be located in centrosome; nucleoplasm; and peroxisome. Predicted to be active in chromosome; cytoplasm; and nucleus. Is expressed in brain; caudal fin; immature eye; and post-vent region. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Chen et al., 2022
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la019487TgTransgenic insertionUnknownUnknownDNA
nya2Allele with one deletionExon 2UnknownCRISPR
sa6364Allele with one point mutationUnknownPremature StopENU
sa14977Allele with one point mutationUnknownSplice SiteENU
sa15974Allele with one point mutationUnknownPremature StopENU
sa17959Allele with one point mutationUnknownSplice SiteENU
sa22587Allele with one point mutationUnknownSplice SiteENU
sa24975Allele with one point mutationUnknownPremature StopENU
sa28405Allele with one point mutationUnknownPremature StopENU
sa35807Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
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Human Disease
Associated With atm Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ataxia telangiectasia Alliance Ataxia-telangiectasia 208900
breast cancer Alliance {Breast cancer, susceptibility to} 114480
Lymphoma, B-cell non-Hodgkin, somatic
Lymphoma, mantle cell, somatic
T-cell prolymphocytic leukemia, somatic
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Associated With atm Via Experimental Models
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Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR003151 PIK-related kinase, FAT
Domain IPR003152 FATC domain
Domain IPR014009 PIK-related kinase
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Domain Details Per Protein
Protein Additional Resources Length ATM, catalytic domain FATC domain Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site PIK-related kinase PIK-related kinase, FAT Protein kinase-like domain superfamily Serine/threonine-protein kinase ATM, plant Telomere-length maintenance and DNA damage repair
UniProtKB:F1QJB6 InterPro 3091
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 15
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA atm-201 (1) Ensembl 9,276 nt
mRNA atm-202 (1) Ensembl 7,428 nt
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Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-121F8ZFIN Curated Data
Contained inFosmidCH1073-349P20ZFIN Curated Data
Contained inFosmidCH1073-449D16ZFIN Curated Data
Contained inFosmidZFOS-598C2ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanATM11
Amino acid sequence comparison (2)
MouseAtm9
Amino acid sequence comparison (2)
Citations
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