Gene
homer1b
- ID
- ZDB-GENE-040801-44
- Name
- homer scaffold protein 1b
- Symbol
- homer1b Nomenclature History
- Previous Names
-
- homer1
- zgc:100854
- zgc:92844
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled glutamate receptor binding activity. Acts upstream of or within intracellular calcium ion homeostasis and muscle structure development. Predicted to be located in cytosol and dendritic spine. Predicted to be active in several cellular components, including dendrite; plasma membrane; and postsynaptic density. Is expressed in several structures, including basal plate midbrain region; cardiovascular system; central nervous system; musculature system; and retina. Orthologous to human HOMER1 (homer scaffold protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7140241 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Lin et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
nv1165 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 1 of 1
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Homer, EVH1 domain | Homer family | PH-like domain superfamily | WH1/EVH1 domain |
---|---|---|---|---|---|---|
UniProtKB:A0A8M9Q8D4 | InterPro | 231 | ||||
UniProtKB:B8JIC5 | InterPro | 398 | ||||
UniProtKB:A0A0R4INT7 | InterPro | 360 | ||||
UniProtKB:A0A8M2B3L5 | InterPro | 193 |
1 - 4 of 4
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
homer1b-202
(1)
|
Ensembl | 2,450 nt | ||
mRNA |
homer1b-203
(1)
|
Ensembl | 2,349 nt | ||
ncRNA |
ottdart00000061888
(1)
|
Ensembl | 1,463 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-262A22 | ZFIN Curated Data | |
Contained in | BAC | RP71-26J15 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7140241 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:92844 | ZFIN Curated Data | |
Encodes | cDNA | MGC:100854 | ZFIN Curated Data |
1 - 5 of 5
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001326290 (1) | 2460 nt | ||
Genomic | GenBank:CT033828 (1) | 154862 nt | ||
Polypeptide | UniProtKB:B8JIC5 (1) | 398 aa |
- Deng, J., Wang, Y., Hu, M., Lin, J., Li, Q., Liu, C., Xu, X. (2022) Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism. Frontiers in molecular neuroscience. 15:904935
- Gabellini, C., Pucci, C., De Cesari, C., Martini, D., Di Lauro, C., Digregorio, M., Norton, W., Zippo, A., Sessa, A., Broccoli, V., Andreazzoli, M. (2022) CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish. International Journal of Molecular Sciences. 24(1):
- Ikeda, A., Yamasaki, C., Kubo, Y., Doi, Y., Komamizu, M., Komatsu, M., Shiozaki, K. (2022) Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 39(4):499-512
- Gao, L., Penglee, R., Huang, Y., Yi, X., Wang, X., Liu, L., Gong, X., Bao, B. (2020) CRISPR/Cas9-induced nos2b mutant zebrafish display behavioral abnormalities. Genes, brain, and behavior. 20(5):e12716
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Frank, D.F., Miller, G.W., Connon, R.E., Geist, J., Lein, P.J. (2017) Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. PeerJ. 5:e4106
- Baraban, S.C., Dinday, M.T., and Hortopan, G.A. (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nature communications. 4:2410
- Lin, C.Y., Chen, J.S., Loo, M.R., Hsiao, C.C., Chang, W.Y., and Tsai, H.J. (2013) MicroRNA-3906 Regulates Fast Muscle Differentiation through Modulating the Target Gene homer-1b in Zebrafish Embryos. PLoS One. 8(7):e70187
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 10 of 10
Show