Gene
dusp2
- ID
- ZDB-GENE-040801-188
- Name
- dual specificity phosphatase 2
- Symbol
- dusp2 Nomenclature History
- Previous Names
-
- wu:fj40g04
- zgc:91929
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable phosphoprotein phosphatase activity. Acts upstream of or within axon regeneration and negative regulation of JNK cascade. Predicted to be active in cytoplasm and nucleus. Is expressed in hindbrain neural plate; mucus secreting cell; nervous system; and presumptive rhombomere 4. Orthologous to human DUSP2 (dual specificity phosphatase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91929 (13 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR001763 | Rhodanese-like domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Dual specificity phosphatase, catalytic domain | Dual specificity protein phosphatase domain | Mitogen-activated protein (MAP) kinase phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Rhodanese-like domain | Rhodanese-like domain superfamily | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DBR5 | InterPro | 333 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- He, X., Wang, Z., Cheng, L., Wang, H., Sun, Y. (2025) An antagonistic role of clock genes and lima1 in kidney regeneration. Communications biology. 8:2929
- Weeks, O., Gao, X., Basu, S., Galdieri, J., Chen, K., Burns, C.G., Burns, C.E. (2024) Embryonic alcohol exposure in zebrafish predisposes adults to cardiomyopathy and diastolic dysfunction. Cardiovascular research. 120(13):1607-1621
- Shao, G.J., Wang, X.L., Wei, M.L., Ren, D.L., Hu, B. (2023) DUSP2 deletion with CRISPR/Cas9 promotes Mauthner cell axonal regeneration at the early stage of zebrafish. Neural regeneration research. 18:577-581
- Sojan, J.M., Gundappa, M.K., Carletti, A., Gaspar, V., Gavaia, P., Maradonna, F., Carnevali, O. (2022) Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism. Frontiers in nutrition. 9:868805
- De Simone, A., Evanitsky, M.N., Hayden, L., Cox, B.D., Wang, J., Tornini, V.A., Ou, J., Chao, A., Poss, K.D., Di Talia, S. (2021) Control of osteoblast regeneration by a train of Erk activity waves. Nature. 590(7844):129-133
- Ghosh, P., Maurer, J.M., Sagerström, C.G. (2018) Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural Development. 13:13
- Maurer, J.M., Sagerström, C.G. (2018) A parental requirement for dual-specificity phosphatase 6 in zebrafish. BMC Developmental Biology. 18:6
- Zhang, J., Zhou, Y., Wu, C., Wan, Y., Fang, C., Li, J., Fang, W., Yi, R., Zhu, G., Li, J., Wang, Y. (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in endocrinology. 9:756
- Hu, P., Liu, M., Liu, Y., Wang, J., Zhang, D., Niu, H., Jiang, S., Wang, J., Zhang, D., Han, B., Xu, Q., Chen, L. (2016) Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Scientific Reports. 6:28952
- Choe, S.K., Zhang, X., Hirsch, N., Straubhaar, J., and Sagerström, C.G. (2011) A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Developmental Biology. 358(2):356-67
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