Gene
nr2e1
- ID
- ZDB-GENE-040801-127
- Name
- nuclear receptor subfamily 2, group E, member 1
- Symbol
- nr2e1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in several structures, including alar plate midbrain region; nervous system; optic vesicle; presumptive diencephalon; and presumptive neural retina. Orthologous to human NR2E1 (nuclear receptor subfamily 2 group E member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:100991 (31 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa37076 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
Family | IPR001723 | Nuclear hormone receptor |
Family | IPR050274 | Nuclear hormone receptor family NR2 subfamily |
Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
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Domain Details Per Protein
Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR2 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q6DEH0 | InterPro | 396 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-10H8 | ZFIN Curated Data | |
Encodes | EST | fc30e03 | ||
Encodes | EST | fc39f12 | ||
Encodes | cDNA | MGC:100991 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001003608 (1) | 2730 nt | ||
Genomic | GenBank:CU138515 (2) | 62544 nt | ||
Polypeptide | UniProtKB:Q6DEH0 (1) | 396 aa |
- Letelier, J., Buono, L., Almuedo-Castillo, M., Zang, J., Mounieres, C., González-Díaz, S., Polvillo, R., Sanabria-Reinoso, E., Corbacho, J., Sousa-Ortega, A., Diez Del Corral, R., Neuhauss, S.C.F., Martínez-Morales, J.R. (2023) Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. eLIFE. 12:
- Gao, L., Yuan, Z., Zhou, T., Yang, Y., Gao, D., Dunham, R., Liu, Z. (2019) FOXO genes in channel catfish and their response after bacterial infection. Developmental and comparative immunology. 97:38-44
- Madelaine, R., Sloan, S.A., Huber, N., Notwell, J.H., Leung, L.C., Skariah, G., Halluin, C., Paşca, S.P., Bejerano, G., Krasnow, M.A., Barres, B.A., Mourrain, P. (2017) MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis. Cell Reports. 20:1533-1542
- David, A.P., Margarit, E., Domizi, P., Banchio, C., Armas, P., Calcaterra, N.B. (2016) G-quadruplexes as novel cis-elements controlling transcription during embryonic development. Nucleic acids research. 44(9):4163-73
- Cheng, Y.Y., Tao, W.J., Chen, J.L., Sun, L.N., Zhou, L.Y., Song, Q., Wang, D.S. (2015) Genome-wide identification, evolution and expression analysis of nuclear receptor superfamily in Nile tilapia, Oreochromis niloticus. Gene. 569(1):141-52
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhao, Y., Zhang, K., Giesy, J.P., Hu, J. (2015) Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective. Scientific Reports. 5:8554
- Bertrand, S., Thisse, B., Tavares, R., Sachs, L., Chaumot, A., Bardet, P.L., Escrivà, H., Duffraisse, M., Marchand, O., Safi, R., Thisse, C., and Laudet, V. (2007) Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. PLoS Genetics. 3(11):e188
- Kitambi, S.S., and Hauptmann, G. (2007) The zebrafish orphan nuclear receptor genes nr2e1 and nr2e3 are expressed in developing eye and forebrain. Gene expression patterns : GEP. 7(4):521-528
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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