Gene
tln2a
- ID
- ZDB-GENE-040724-263
- Name
- talin 2a
- Symbol
- tln2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Predicted to be involved in actin cytoskeleton organization and cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be located in cytoskeleton and ruffle. Predicted to be active in cytoplasm; focal adhesion; and plasma membrane. Is expressed in brain; ectoderm; head; paraxial mesoderm; and somite. Orthologous to human TLN2 (talin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wu et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029324Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa3330 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34090 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40914 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45280 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sk113 | Allele with multiple variants | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tln2a | Yamaguchi et al., 2022 | |
| CRISPR2-tln2a | Yamaguchi et al., 2022 | |
| CRISPR3-tln2a | Yamaguchi et al., 2022 | |
| CRISPR4-tln2a | Yamaguchi et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-catenin/vinculin-like superfamily | Band 4.1 domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM conserved site | FERM domain | FERM superfamily, second domain | I/LWEQ domain | I/LWEQ domain superfamily | IRS-type PTB domain | PH-like domain superfamily | Talin-1/2, rod-segment | Talin 1-like, rod-segment domain | Talin, central | Talin, central domain superfamily | Talin, IBS2B domain | Talin, N-terminal F0 domain | Talin, R4 domain | Ubiquitin-like domain superfamily | Vinculin-binding site-containing domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z7P4 | InterPro | 2548 | ||||||||||||||||||||
| UniProtKB:A0A8M2BG54 | InterPro | 2545 | ||||||||||||||||||||
| UniProtKB:A0A0R4IIA7 | InterPro | 2543 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-148P15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-88A11 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-132M23 | ||
| Encodes | cDNA | MGC:63613 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152648 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193093 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201193 (1) | 7801 nt | ||
| Genomic | GenBank:CT030047 (1) | 251691 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z7P4 (1) | 2548 aa |
- Yamaguchi, N., Zhang, Z., Schneider, T., Wang, B., Panozzo, D., Knaut, H. (2022) Rear traction forces drive adherent tissue migration in vivo. Nature cell biology. 24:194-204
- Cheung, C.T., Nguyen, T.V., Le Cam, A., Patinote, A., Journot, L., Reynes, C., Bobe, J. (2019) What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. BMC Genomics. 20:584
- Gunawan, F., Gentile, A., Fukuda, R., Tsedeke, A.T., Jiménez-Amilburu, V., Ramadass, R., Iida, A., Sehara-Fujisawa, A., Stainier, D.Y.R. (2019) Focal adhesions are essential to drive zebrafish heart valve morphogenesis. The Journal of cell biology. 218(3):1039-1054
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Thomas-Jinu, S., Gordon, P.M., Fielding, T., Taylor, R., Smith, B.N., Snowden, V., Blanc, E., Vance, C., Topp, S., Wong, C.H., Bielen, H., Williams, K.L., McCann, E.P., Nicholson, G.A., Pan-Vazquez, A., Fox, A.H., Bond, C.S., Talbot, W.S., Blair, I.P., Shaw, C.E., Houart, C. (2017) Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Neuron. 94(2):322-336.e5
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Wu, Q., Zhang, J., Koh, W., Yu, Q., Zhu, X., Amsterdam, A., Davis, G.E., Arnaout, M.A., Xiong, J.W. (2015) Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(12):4989-5005
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Veerkamp, J., Rudolph, F., Cseresnyes, Z., Priller, F., Otten, C., Renz, M., Schaefer, L., and Abdelilah-Seyfried, S. (2013) Unilateral dampening of bmp activity by nodal generates cardiac left-right asymmetry. Developmental Cell. 24(6):660-667
- Cañestro, C., Catchen, J.M., Rodriguez-Mari, A., Yokoi, H., and Postlethwait, J.H. (2009) Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes. PLoS Genetics. 5(5):e1000496
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