Gene
hrh3
- ID
- ZDB-GENE-040724-204
- Name
- histamine receptor H3
- Symbol
- hrh3 Nomenclature History
- Previous Names
-
- si:rp71-34g2.4
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables histamine receptor activity. Predicted to be involved in adenylate cyclase-activating adrenergic receptor signaling pathway and positive regulation of MAPK cascade. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; heart; and spleen. Orthologous to human HRH3 (histamine receptor H3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct839 | Allele with one deletion | Unknown | Frameshift, Premature Stop | zinc finger nuclease | |
| hki2 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| nv1446 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa40981 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uol1 | Allele with one insertion | Exon 1 | Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hrh3 | Puttonen et al., 2017 | |
| CRISPR2-hrh3 | Reichmann et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Histamine H3 receptor | Histamine H3 receptor, 7TM |
|---|---|---|---|---|---|---|
| UniProtKB:Q6ZM33 | InterPro | 473 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-34G2 | ||
| Encodes | cDNA | MGC:194150 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194163 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025518 (1) | 1422 nt | ||
| Genomic | GenBank:AL928906 (1) | 161527 nt | ||
| Polypeptide | UniProtKB:Q6ZM33 (1) | 473 aa |
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Baronio, D., Chen, Y.C., Panula, P. (2021) Abnormal brain development of monoamine oxidase mutant zebrafish and impaired social interaction of heterozygous fish. Disease models & mechanisms. 15(3):
- Sundvik, M., Puttonen, H., Semenova, S., Panula, P. (2021) The bullies are the leaders of the next generation: inherited aminergic neurotransmitter system changes in socially dominant zebrafish, Danio rerio. Behavioural brain research. 409:113309
- Reichmann, F., Rimmer, N., Tilley, C.A., Dalla Vecchia, E., Pinion, J., Al Oustah, A., Carreño Gutiérrez, H., Young, A.M., McDearmid, J.R., Winter, M.J., Norton, W.H. (2020) The zebrafish histamine H3 receptor modulates aggression, neural activity and forebrain functional connectivity. Acta physiologica (Oxford, England). 230(4):e13543
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Chen, A., Singh, C., Oikonomou, G., Prober, D.A. (2017) Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep. eNeuro. 4(1)
- Puttonen, H.A.J., Sundvik, M., Semenova, S., Shirai, Y., Chen, Y.C., Panula, P. (2017) Knock-out of histamine receptor H3 alters adaptation to sudden darkness and monoamine levels in the zebrafish. Acta physiologica (Oxford, England). 222(3)
- Norton, W.H., Stumpenhorst, K., Faus-Kessler, T., Folchert, A., Rohner, N., Harris, M.P., Callebert, J., and Bally-Cuif, L. (2011) Modulation of Fgfr1a Signaling in Zebrafish Reveals a Genetic Basis for the Aggression-Boldness Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(39):13796-13807
- Sundvik, M., Kudo, H., Toivonen, P., Rozov, S., Chen, Y.C., and Panula, P. (2011) The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25(12):4338-47
- Peitsaro, N., Sundvik, M., Anichtchik, O.V., Kaslin, J., and Panula, P. (2007) Identification of zebrafish histamine H(1), H(2) and H(3) receptors and effects of histaminergic ligands on behavior. Biochemical pharmacology. 73(8):1205-1214
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