Gene

kdm6bb

ID

ZDB-GENE-040724-166

Name

lysine (K)-specific demethylase 6B, b

Symbol

kdm6bb Nomenclature History

Previous Names

kdm6b
jmjd3
jmjd3a (1)
si:ch211-237l4.7

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Enables histone H3K27me2/H3K27me3 demethylase activity and histone H3K27me3 reader activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; fin regeneration; and primitive erythrocyte differentiation. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Is expressed in caudal hematopoietic tissue; central nervous system; heart; and otic vesicle. Human ortholog(s) of this gene implicated in Stolerman neurodevelopmental syndrome. Orthologous to human KDM6B (lysine demethylase 6B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kdm6bb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Stolerman neurodevelopmental syndrome	Alliance	Stolerman neurodevelopmental syndrome	618505

Associated With kdm6bb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003347	JmjC domain
Domain	IPR048560	Lysine-specific demethylase 6A/B-like, GATA-like
Domain	IPR048562	Lysine-specific demethylase 6A/B-like, C-terminal helical domain
Family	IPR051630	Transcriptional Corepressor and Histone Demethylase
Homologous_superfamily	IPR046941	Lysine-specific demethylase 6, GATA-like domain superfamily