Gene
gata2b
- ID
- ZDB-GENE-040718-440
- Name
- GATA binding protein 2b
- Symbol
- gata2b Nomenclature History
- Previous Names
-
- zgc:91840 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within definitive hemopoiesis and hematopoietic stem cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; caudal fin; endothelial cell; hematopoietic system; and neurons. Human ortholog(s) of this gene implicated in acute myeloid leukemia; depressive disorder; immunodeficiency 21; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91840 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cz1crspr | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| cz2crspr | Allele with one insertion | Exon 4 | Unknown | CRISPR | |
| hg94 | Allele with one insertion | Exon 2 | Frameshift | CRISPR | |
| hg95 | Allele with one deletion | Exon 4 | Frameshift | CRISPR | |
| hg133Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| re27 | Allele with one insertion | Exon 3 | Unknown | CRISPR | |
| sa14633 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| u5008 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 8 of 8
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gata2b | (2) | |
| CRISPR2-gata2b | (2) | |
| CRISPR3-gata2b | Dobrzycki et al., 2020 | |
| CRISPR4-gata2b | Avagyan et al., 2021 | |
| CRISPR5-gata2b | Avagyan et al., 2021 | |
| CRISPR6-gata2b | (3) | |
| CRISPR7-gata2b | Bresciani et al., 2021 | |
| CRISPR8-gata2b | (2) | |
| CRISPR9-gata2b | (2) | |
| MO1-gata2b | N/A | (3) |
1 - 10 of 11
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | {Leukemia, acute myeloid, susceptibility to} | 601626 |
| immunodeficiency 21 | Alliance | Immunodeficiency 21 | 614172 |
| myelodysplastic syndrome | Alliance | {Myelodysplastic syndrome, susceptibility to} | 614286 |
| Emberger syndrome | 614038 |
1 - 4 of 4
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcription factor GATA | Transcription factor, GATA-2/3 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|---|
| UniProtKB:F1QD30 | InterPro | 428 | ||||
| UniProtKB:Q6DG89 | InterPro | 427 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gata2b-201
(1)
|
Ensembl | 1,955 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(gata2b:KALTA4) |
|
| 1 | (12) |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-157B11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:91840 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192890 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002689 (1) | 1953 nt | ||
| Genomic | GenBank:CR450814 (1) | 158142 nt | ||
| Polypeptide | UniProtKB:F1QD30 (1) | 428 aa |
- Campbell, C.A., Calderon, R., Pavani, G., Cheng, X., Barakat, R., Snella, E., Liu, F., Peng, X., Essner, J.J., Dorman, K.S., McGrail, M., Gadue, P., French, D.L., Espin-Palazon, R. (2024) p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nature communications. 15:77877787
- Gioacchino, E., Zhang, W., Koyunlar, C., Zink, J., de Looper, H., Gussinklo, K.J., Hoogenboezem, R., Bosch, D., Bindels, E., Touw, I.P., de Pater, E. (2024) GATA2 heterozygosity causes an epigenetic feedback mechanism resulting in myeloid and erythroid dysplasia. British journal of haematology. 205(2):580-593
- Liu, X., Sha, J., Wang, L., Wang, Z., Fang, Z., Han, X., Tan, S., Chen, Y., Yuan, H., De The, H., Zhou, J., Zhu, J. (2024) Rnf111 has a pivotal role in regulating development of definitive hematopoietic stem and progenitor cells through the Smad2/3-Gcsfr/NO axis in zebrafish. Haematologica. :
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Cacialli, P., Dogan, S., Linnerz, T., Pasche, C., Bertrand, J.Y. (2023) Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo. Stem Cell Reports. 18:153415461534-1546
- Koyunlar, C., Gioacchino, E., Vadgama, D., de Looper, H.W.J., Zink, J., Ter Borg, M., Hoogenboezem, R., Havermans, M., Sanders, M.A., Bindels, E., Dzierzak, E.A., Touw, I.P., de Pater, E. (2023) Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition. Blood advances. 7(10):2082-2093
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Liu, X., Zhou, L., Li, W., Wu, J., Wang, D. (2023) Gata2a Mutation Causes Progressive Microphthalmia and Blindness in Nile Tilapia. International Journal of Molecular Sciences. 24(4):
- Tamaoki, J., Maeda, H., Kobayashi, I., Takeuchi, M., Ohashi, K., Gore, A., Bonkhofer, F., Patient, R., Weinstein, B.M., Kobayashi, M. (2023) LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition. Developmental Biology. 501:92-103
- Carrington, B., Ramanagoudr-Bhojappa, R., Bresciani, E., Han, T.U., Sood, R. (2022) A robust pipeline for efficient knock-in of point mutations and epitope tags in zebrafish using fluorescent PCR based screening. BMC Genomics. 23:810810
1 - 10 of 57
Show