Gene
cryabb
- ID
- ZDB-GENE-040718-419
- Name
- crystallin, alpha B, b
- Symbol
- cryabb Nomenclature History
- Previous Names
-
- cryab2
- fe37f08
- hspb5b (1)
- wu:fe37f08
- zgc:91937
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables unfolded protein binding activity. Acts upstream of or within several processes, including heart contraction; maintenance of lens transparency; and myofibril assembly. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; heart; lens; liver; and otic vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAB (crystallin alpha B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91937 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cryabb | (2) | |
| CRISPR2-cryabb | (2) | |
| CRISPR3-cryabb | (2) | |
| CRISPR4-cryabb | (2) | |
| CRISPR5-cryabb | Mercer et al., 2018 | |
| CRISPR6-cryabb | (2) | |
| MO1-cryabb | N/A | Bührdel et al., 2015 |
| MO2-cryabb | N/A | Zou et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| adult-onset myofibrillar myopathy 2A | Alliance | Myopathy, myofibrillar, 2A, adult-onset | 608810 |
| cataract 16 multiple types | Alliance | Cataract 16, multiple types | 613763 |
| dilated cardiomyopathy 1II | Alliance | Cardiomyopathy, dilated, 1II | 615184 |
| infantile-onset myofibrillar myopathy-2B | Alliance | Myopathy, myofibrillar, 2B, infantile-onset | 613869 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cataract | cryabbasu3/asu3 | standard conditions | Posner et al., 2024 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha crystallin/Hsp20 domain | Alpha-crystallin, N-terminal | Alpha crystallin/Small heat shock protein, animal type | HSP20-like chaperone |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q8E3 | InterPro | 180 | ||||
| UniProtKB:Q6DG35 | InterPro | 165 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cryabb-201
(1)
|
Ensembl | 1,003 nt | ||
| mRNA |
cryabb-202
(1)
|
Ensembl | 952 nt | ||
| mRNA |
cryabb-203
(1)
|
Ensembl | 2,192 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(cryaa:cryabb,myl7:TagRFP) |
|
| 1 | Mishra et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-128B20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-202F5 | ZFIN Curated Data | |
| Encodes | EST | fe37f08 | ||
| Encodes | cDNA | MGC:91937 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191143 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002670 (1) | 2192 nt | ||
| Genomic | GenBank:BX510338 (2) | 209337 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q8E3 (1) | 180 aa |
- Posner, M., Garver, T., Kaye, T., Brdicka, S., Suttle, M., Patterson, B., Farnsworth, D.R. (2024) Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens. Experimental Eye Research. 244:109918
- Posner, M., Murray, K.L., Andrew, B., Brdicka, S., Roberts, A., Franklin, K., Hussen, A., Kaye, T., Kepp, E., McDonald, M.S., Snodgrass, T., Zientek, K., David, L.L. (2022) Impact of α-crystallin protein loss on zebrafish lens development. Experimental Eye Research. 227:109358
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Gou, D., Zhou, J., Song, Q., Wang, Z., Bai, X., Zhang, Y., Zuo, M., Wang, F., Chen, A., Yousaf, M., Yang, Z., Peng, H., Li, K., Xie, W., Tang, J., Yao, Y., Han, M., Ke, T., Chen, Q., Xu, C., Wang, Q. (2020) Mog1 knockout causes cardiac hypertrophy and heart failure by downregulating tbx5-cryab-hspb2 signaling in zebrafish. Acta physiologica (Oxford, England). 231(3):e13567
- Posner, M., McDonald, M.S., Murray, K.L., Kiss, A.J. (2019) Why does the zebrafish cloche mutant develop lens cataract?. PLoS One. 14:e0211399
- Hsieh, F.C., Lu, Y.F., Liau, I., Chen, C.C., Cheng, C.M., Hsiao, C.D., Hwang, S.L. (2018) Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells. Scientific Reports. 8:7856
- Mercer, E.J., Lin, Y.F., Cohen-Gould, L., Evans, T. (2018) Hspb7 is a Cardioprotective Chaperone Facilitating Sarcomeric Proteostasis. Developmental Biology. 435(1):41-55
- Mishra, S., Wu, S.Y., Fuller, A.W., Wang, Z., Rose, K.L., Schey, K.L., Mchaourab, H.S. (2018) Loss of αB-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart. The Journal of biological chemistry. 293(2):740-753
- Wu, S.Y., Zou, P., Mishra, S., Mchaourab, H.S. (2018) Transgenic zebrafish models reveal distinct molecular mechanisms for cataract-linked αA-crystallin mutants. PLoS One. 13:e0207540
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