Gene
rxrgb
- ID
- ZDB-GENE-040718-34
- Name
- retinoid X receptor, gamma b
- Symbol
- rxrgb Nomenclature History
- Previous Names
-
- nr2b3b (1)
- zgc:92183
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable nuclear receptor activity and retinoic acid-responsive element binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and retinoic acid receptor signaling pathway. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including Kupffer's vesicle; central nervous system; liver; paraxial mesoderm; and retina. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human RXRG (retinoid X receptor gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- bc075918 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
Domain | IPR021780 | Nuclear/hormone receptor activator site AF-1 |
Family | IPR000003 | Retinoid X receptor/HNF4 |
Family | IPR001723 | Nuclear hormone receptor |
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Domain Details Per Protein
Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear/hormone receptor activator site AF-1 | Nuclear hormone receptor family NR2 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Retinoid X receptor/HNF4 | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B7K1 | InterPro | 465 | ||||||||
UniProtKB:Q6DHP9 | InterPro | 452 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-260G14 | ZFIN Curated Data | |
Encodes | EST | bc075918 | Bertrand et al., 2007 | |
Encodes | EST | fa03b10 | ZFIN Curated Data | |
Encodes | cDNA | MGC:92183 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001002345 (1) | 1846 nt | ||
Genomic | GenBank:BX296562 (1) | 129328 nt | ||
Polypeptide | UniProtKB:A0A8M2B7K1 (1) | 465 aa |
- Gray, R., Lovely, C.B. (2024) Redefining retinoic acid receptor expression in zebrafish embryos using Hybridization Chain Reaction. Differentiation; research in biological diversity. 140:100822
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171
- Tao, J., Bai, C., Chen, Y., Zhou, H., Liu, Y., Shi, Q., Pan, W., Dong, H., Li, L., Xu, H., Tanguay, R., Huang, C., Dong, Q. (2020) Environmental relevant concentrations of benzophenone-3 induced developmental neurotoxicity in zebrafish. The Science of the total environment. 721:137686
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Lin, S.J., Chiang, M.C., Shih, H.Y., Chiang, K.C., Cheng, Y.C. (2017) Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. Development genes and evolution. 227(3):219-230
- Wu, Y., Su, G., Tang, S., Liu, W., Ma, Z., Zheng, X., Liu, H., Yu, H. (2017) The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Chemosphere. 168:122-130
- Cheng, J., Lv, S., Nie, S., Liu, J., Tong, S., Kang, N., Xiao, Y., Dong, Q., Huang, C., Yang, D. (2016) Chronic perfluorooctane sulfonate (PFOS) exposure induces hepatic steatosis in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 176:45-52
- Cunha, V., Rodrigues, P., Santos, M.M., Moradas-Ferreira, P., Ferreira, M. (2016) Danio rerio embryos on Prozac - Effects on the detoxification mechanism and embryo development. Aquatic toxicology (Amsterdam, Netherlands). 178:182-189
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
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