Gene
atp6v1f
- ID
- ZDB-GENE-040718-259
- Name
- ATPase H+ transporting V1 subunit F
- Symbol
- atp6v1f Nomenclature History
- Previous Names
-
- zgc:92923
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable proton-transporting ATPase activity, rotational mechanism. Acts upstream of or within several processes, including Kupffer's vesicle development; apical protein localization; and notochord cell vacuolation. Located in plasma membrane. Is expressed in central nervous system; diencephalon; epiphysis; mucus secreting cell; and telencephalon. Orthologous to human ATP6V1F (ATPase H+ transporting V1 subunit F).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92923 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi1988Tg | Transgenic insertion | Exon 1 | Unknown | DNA | |
| la015363Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ATPase, V1 complex, subunit F | ATPase, V1 complex, subunit F, eukaryotic | ATPase, V1 complex, subunit F superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q6DRK0 | InterPro | 119 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp6v1f-201
(1)
|
Ensembl | 778 nt | ||
| ncRNA |
atp6v1f-002
(1)
|
Ensembl | 619 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-159A18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92923 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192096 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002526 (1) | 995 nt | ||
| Genomic | GenBank:BX890616 (1) | 74749 nt | ||
| Polypeptide | UniProtKB:Q6DRK0 (1) | 119 aa |
- Santra, P., Amack, J.D. (2021) Loss of vacuolar-type H+-ATPase induces caspase-independent necrosis-like death of hair cells in zebrafish neuromasts. Disease models & mechanisms. 14(7):
- Levic, D.S., Ryan, S., Marjoram, L., Honeycutt, J., Bagwell, J., Bagnat, M. (2020) Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish. The Journal of cell biology. 219(4):
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gokey, J.J., Dasgupta, A., Amack, J.D. (2015) The V-ATPase accessory protein Atp6ap1b mediates dorsal forerunner cell proliferation and left-right asymmetry in zebrafish. Developmental Biology. 407(1):115-30
- Alvers, A.L., Ryan, S., Scherz, P.J., Huisken, J., and Bagnat, M. (2014) Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling. Development (Cambridge, England). 141(5):1110-1119
- Ellis, K., Bagwell, J., and Bagnat, M. (2013) Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. The Journal of cell biology. 200(5):667-679
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Hwang, J., Kim, H.S., Seok, J.W., Kim, J.D., Koun, S., Park, S.Y., Lee, J., Kim, H.S., Kim, H.S., Kim, K.S., Chang, K.T., Ryoo, Z.Y., Wang, S.M., Huh, T.L., and Lee, S. (2009) Transcriptome analysis of the zebrafish mind bomb mutant. Molecular genetics and genomics : MGG. 281(1):77-85
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