Gene
rac3a
- ID
- ZDB-GENE-040718-256
- Name
- Rac family small GTPase 3a
- Symbol
- rac3a Nomenclature History
- Previous Names
-
- rac3 (1)
- wu:fb95b01
- zgc:100831
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; cytoskeleton organization; and motor neuron axon guidance. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuron projection. Is expressed in blastomere; hatching gland; nervous system; somite; and trigeminal placode. Orthologous to human RAC3 (Rac family small GTPase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138689 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la015193Tg | Transgenic insertion | Unknown | Unknown | DNA |
1 - 1 of 1
Show
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies | 618577 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding domain |
---|---|---|---|---|---|---|
UniProtKB:Q6DGB7 | InterPro | 192 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-117C2 | ZFIN Curated Data | |
Contained in | BAC | CH211-234H8 | ZFIN Curated Data | |
Encodes | EST | fb95b01 | Rauch et al., 2003 | |
Encodes | EST | IMAGE:7138689 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:100831 | ZFIN Curated Data |
1 - 5 of 5
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001002754 (1) | 1706 nt | ||
Genomic | GenBank:BX897685 (1) | 179286 nt | ||
Polypeptide | UniProtKB:Q6DGB7 (1) | 192 aa |
- Lu, Y., Tang, D., Zheng, Z., Wang, X., Zuo, N., Yan, R., Wu, C., Ma, J., Wang, C., Xu, H., He, Y., Liu, D., Liu, S. (2022) Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Frontiers in molecular neuroscience. 15:844668
- Letelier, J., Terriente, J., Belzunce, I., Voltes, A., Undurraga, C.A., Polvillo, R., Devos, L., Tena, J.J., Maeso, I., Retaux, S., Gomez-Skarmeta, J.L., Martínez-Morales, J.R., Pujades, C. (2018) Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation.. Proceedings of the National Academy of Sciences of the United States of America. 115(16):E3731-E3740
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Rosowski, E.E., Deng, Q., Keller, N.P., Huttenlocher, A. (2016) Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 197(12):4780-4790
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Dhliwayo, N., Sarras, M.P., Luczkowski, E., Mason, S., Intine, R.V. (2014) Parp inhibition prevents ten eleven translocase enzyme activation and hyperglycemia induced DNA demethylation. Diabetes... 63(9):3069-76
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Tell, R.M., Kimura, K., and Pali, D. (2012) Rac2 expression and its role in neutrophil functions of zebrafish (Danio rerio). Fish & shellfish immunology. 33(5):1086-1094
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Salas-Vidal, E., Meijer, A.H., Cheng, X., and Spaink, H.P. (2005) Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Genomics. 86(1):25-37
1 - 10 of 11
Show