Gene
nup205
- ID
- ZDB-GENE-040715-8
- Name
- nucleoporin 205
- Symbol
- nup205 Nomenclature History
- Previous Names
-
- zgc:111802
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nuclear pore organization. Predicted to be located in nucleus. Predicted to be part of nuclear pore inner ring. Human ortholog(s) of this gene implicated in nephrotic syndrome type 13. Orthologous to human NUP205 (nucleoporin 205).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi557Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| hi2352Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| hi2720Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| hi2992Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| sa6122 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6504 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14979 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa25054 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43058 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43059 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 13 | Alliance | ?Nephrotic syndrome, type 13 | 616893 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR021827 | Nucleoporin Nup186/Nup192/Nup205 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleoporin Nup186/Nup192/Nup205 |
|---|---|---|---|
| UniProtKB:A0A8M9PFD6 | InterPro | 2013 | |
| UniProtKB:F1QJ18 | InterPro | 1970 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nup205-201
(1)
|
Ensembl | 6,108 nt | ||
| mRNA |
nup205-202
(1)
|
Ensembl | 6,006 nt | ||
| mRNA |
nup205-203
(1)
|
Ensembl | 6,006 nt | ||
| mRNA |
nup205-204
(1)
|
Ensembl | 6,109 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-141E22 | ZFIN Curated Data | |
| Contained in | BAC | CH211-269A1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-57M7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111802 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001313687 (1) | 6108 nt | ||
| Genomic | GenBank:CR293524 (1) | 190196 nt | ||
| Polypeptide | UniProtKB:A0A8M9PFD6 (1) | 2013 aa |
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S., Haldi, M., Artzt, K., Farrington, S., Lin, S.Y., Nissen, R.M., and Hopkins, N. (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nature Genetics. 31(2):135-140
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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