Gene
polr2d
- ID
- ZDB-GENE-040714-2
- Name
- RNA polymerase II subunit D
- Symbol
- polr2d Nomenclature History
- Previous Names
-
- rnap
- wu:fa95b11
- zgc:110435
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable translation initiation factor binding activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to act upstream of or within DNA-templated transcription initiation. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Is expressed in several structures, including blastomere; heart; liver; nervous system; and pleuroperitoneal region. Orthologous to human POLR2D (RNA polymerase II subunit D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110435 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006590 | RNA polymerase Rpb4/RPC9, core |
| Family | IPR005574 | RNA polymerase subunit Rpb4/RPC9 |
| Family | IPR045222 | DNA-directed RNA polymerase II subunit Rpb4-like |
| Homologous_superfamily | IPR010997 | HRDC-like superfamily |
| Homologous_superfamily | IPR038324 | Rpb4/RPC9 superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DNA-directed RNA polymerase II subunit Rpb4-like | HRDC-like superfamily | RNA polymerase Rpb4/RPC9, core | RNA polymerase subunit Rpb4/RPC9 | Rpb4/RPC9 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1N062 | InterPro | 145 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
polr2d-201
(1)
|
Ensembl | 613 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-165M22 | ZFIN Curated Data | |
| Encodes | EST | fa95b11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110435 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191453 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002317 (1) | 655 nt | ||
| Genomic | GenBank:CU638696 (1) | 32978 nt | ||
| Polypeptide | UniProtKB:A0A8M1N062 (1) | 145 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | POLR2D | 2 | Nucleotide sequence comparison (1) |
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Rochon, E.R., Xue, J., Mohammed, M.S., Smith, C., Hay-Schmidt, A., DeMartino, A.W., Clark, A., Xu, Q., Lo, C.W., Tsang, M., Tejero, J., Gladwin, M.T., Corti, P. (2023) Cytoglobin regulates NO-dependent cilia motility and organ laterality during development. Nature communications. 14:83338333
- Zuppo, D.A., Missinato, M.A., Santana-Santos, L., Li, G., Benos, P.V., Tsang, M. (2023) Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Development (Cambridge, England). 150(6):
- Malbouyres, M., Guiraud, A., Lefrançois, C., Salamito, M., Nauroy, P., Bernard, L., Sohm, F., Allard, B., Ruggiero, F. (2022) Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish. Matrix biology : journal of the International Society for Matrix Biology. 109:1-18
- van de Pol, I.L.E., Hermaniuk, A., Verberk, W.C.E.P. (2021) Interacting Effects of Cell Size and Temperature on Gene Expression, Growth, Development and Swimming Performance in Larval Zebrafish. Frontiers in Physiology. 12:738804
- Berger, J., Li, M., Berger, S., Meilak, M., Rientjes, J., Currie, P.D. (2020) Effect of Ataluren on dystrophin mutations. Journal of Cellular and Molecular Medicine. 24(12):6680-6689
- Maeta, M., Kataoka, M., Nishiya, Y., Ogino, K., Kashima, M., Hirata, H. (2020) RNA polymerase II subunit D is essential for zebrafish development. Scientific Reports. 10:13213
- van de Pol, I.L.E., Flik, G., Verberk, W.C.E.P. (2020) Triploidy in zebrafish larvae: Effects on gene expression, cell size and cell number, growth, development and swimming performance. PLoS One. 15:e0229468
- Liao, M., Kundap, U., Rosch, R.E., Burrows, D.R.W., Meyer, M.P., Bencheikh, B.O.A., Cossette, P., Samarut, É. (2019) Targeted knockout of GABA receptor gamma 2 subunit provokes transient light-induced reflex seizures in zebrafish larvae. Disease models & mechanisms. 12(11):
- Rochon, E., Missinato, M.A., Xue, J., Tejero, J., Tsang, M., Gladwin, M.T., Corti, P. (2019) Nitrite improves heart regeneration in zebrafish. Antioxidants & redox signaling. 32(6):363-377
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