Gene

cep41

ID
ZDB-GENE-040704-35
Name
centrosomal protein 41
Symbol
cep41 Nomenclature History
Previous Names
  • tsga14
  • zgc:91859
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Enables tubulin-glutamic acid ligase activity. Involved in cilium assembly and protein polyglutamylation. Acts upstream of or within angiogenesis; axoneme assembly; and neural crest cell migration. Predicted to be located in centriole and cilium. Predicted to be active in ciliary basal body. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; immature eye; nervous system; and pronephric duct. Human ortholog(s) of this gene implicated in Joubert syndrome 15. Orthologous to human CEP41 (centrosomal protein 41).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
skk1Allele with one deletionUnknownFrameshift, Premature StopCRISPR
1 - 1 of 1
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-cep41Ki et al., 2019
MO1-cep41N/A (3)
MO2-cep41N/AKi et al., 2019
1 - 3 of 3
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Human Disease
Associated With cep41 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Joubert syndrome 15 Alliance Joubert syndrome 15 614464
1 - 1 of 1
Associated With cep41 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001763 Rhodanese-like domain
Family IPR051889 Centrosomal protein 41
Homologous_superfamily IPR036873 Rhodanese-like domain superfamily
1 - 3 of 3
Domain Details Per Protein
Protein Additional Resources Length Centrosomal protein 41 Rhodanese-like domain Rhodanese-like domain superfamily
UniProtKB:Q6GQN0 InterPro 374
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cep41-201 (1) Ensembl 1,229 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-194I19ZFIN Curated Data
EncodescDNAMGC:91859ZFIN Curated Data
1 - 2 of 2
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCEP417
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 5 of 5
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