Gene
cnr2
- ID
- ZDB-GENE-040702-7
- Name
- cannabinoid receptor 2
- Symbol
- cnr2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable cannabinoid receptor activity. Acts upstream of or within several processes, including hematopoietic stem cell differentiation; hematopoietic stem cell migration to bone marrow; and methionine metabolic process. Predicted to be located in membrane and neuron projection. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including digestive system; gill; heart; hematopoietic system; and nervous system. Used to study anxiety disorder. Orthologous to human CNR2 (cannabinoid receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa36197 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| upr1 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zf426 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | zinc finger nuclease | |
| zf427 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | zinc finger nuclease | |
| zf680 | Allele with one deletion | Exon 1 | Premature Stop | TALEN |
1 - 5 of 5
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cnr2 | (2) | |
| MO1-cnr2 | N/A | Nishio et al., 2012 |
| MO2-cnr2 | N/A | (3) |
| MO3-cnr2 | N/A | Liu et al., 2016 |
| TALEN1-cnr2 | Liu et al., 2016 |
1 - 5 of 5
Show
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| anxiety disorder | cnr2upr1/upr1 (NHGRI-1) | standard conditions | Acevedo-Canabal et al., 2019 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cannabinoid receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:Q20HN0 | InterPro | 383 | |||
| UniProtKB:A0AB32T6I4 | InterPro | 383 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-66C10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194707 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194735 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212964 (1) | 1228 nt | ||
| Genomic | GenBank:AL844887 (1) | 243870 nt | ||
| Polypeptide | UniProtKB:A0AB32T6I4 (1) | 383 aa |
- Park, Y.M., Dahlem, C., Meyer, M.R., Kiemer, A.K., Müller, R., Herrmann, J. (2022) Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism. Molecules. 27(4):
- Son, H.W., Ali, D.W. (2022) Endocannabinoid Receptor Expression in Early Zebrafish Development. Developmental neuroscience. 44(3):142-152
- Knuth, M.M., Stutts, W.L., Ritter, M.M., Garrard, K.P., Kullman, S.W. (2021) Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish. Journal of Lipid Research. 62:100142
- Acevedo-Canabal, A., Colón-Cruz, L., Rodriguez-Morales, R., Varshney, G.K., Burgess, S., González-Sepúlveda, L., Yudowski, G., Behra, M. (2019) Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2. Cannabis and cannabinoid research. 4:88-101
- Forner-Piquer, I., Santangeli, S., Maradonna, F., Rabbito, A., Piscitelli, F., Habibi, H.R., Di Marzo, V., Carnevali, O. (2018) Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. Environmental pollution (Barking, Essex : 1987). 241:1-8
- Forner-Piquer, I., Santangeli, S., Maradonna, F., Verde, R., Piscitelli, F., di Marzo, V., Habibi, H.R., Carnevali, O. (2018) Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish. Chemosphere. 205:118-125
- Krug, R.G., Lee, H.B., El Khoury, L.Y., Sigafoos, A.N., Petersen, M.O., Clark, K.J. (2018) The endocannabinoid gene faah2a modulates stress-associated behavior in zebrafish. PLoS One. 13:e0190897
- Forner-Piquer, I., Maradonna, F., Gioacchini, G., Santangeli, S., Allarà, M., Piscitelli, F., Habibi, H.R., Di Marzo, V., Carnevali, O. (2017) Dose - specific effects of Di-isononyl phthalate on the endocannabinoid system and on liver of female zebrafish. Endocrinology. 158(10):3462-3476
- Gallagher, T.L., Tietz, K.T., Morrow, Z.T., McCammon, J.M., Goldrich, M.L., Derr, N.L., Amacher, S.L. (2017) Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation. Developmental Biology. 429(1):225-239
- Gioacchini, G., Rossi, G., Carnevali, O. (2017) Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches. Scientific Reports. 7:1261
1 - 10 of 22
Show